Setting description

Hormone_therapies more effective in the TP53- & AR- biomarker signature

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.094, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 10.4, median = 7.5 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1.18, hr = 0.84 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.094, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 10.4, median = 7.5 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1.18, hr = 0.84 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.094, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 10.4, median = 7.5 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1.18, hr = 0.84 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 35 4 2 2
TP53- & AR- 405 1 1 3
TP53+ 3 9 3 4
DRD+ 7 0 1 2
TEfus+ 10 3 2 3
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.070 0.008 0.004 0.004
TP53- & AR- 0.810 0.002 0.002 0.006
TP53+ 0.006 0.018 0.006 0.008
DRD+ 0.014 0.000 0.002 0.004
TEfus+ 0.020 0.006 0.004 0.006
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 1 3 2 3
TP53- & AR- 2 396 391 382
TP53+ 29 29 35 30
DRD+ 2 40 41 42
TEfus+ 3 48 42 30
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.002 0.006 0.004 0.006
TP53- & AR- 0.004 0.792 0.782 0.764
TP53+ 0.058 0.058 0.070 0.060
DRD+ 0.004 0.080 0.082 0.084
TEfus+ 0.006 0.096 0.084 0.060
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 49 11 16 27
TP53+ 10 12 8 9
DRD+ 0 0 0 0
TEfus+ 0 0 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.098 0.022 0.032 0.054
TP53+ 0.020 0.024 0.016 0.018
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.000


Errors & power

The overall error was 0.132.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.062             0.034             0.016             0.028 

The overall power was 0.81.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
             0.81              0.00              0.00              0.00 

Median results at the end of the trial

By signature:
signature var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
all graduation 2 0 35 2 4
futility 2 0 1 3 3
max_n 0 0 0 0 0
n 166 (119, 235) 418 (351, 460) 158 (95, 262) 167 (122, 252) 168 (120, 246)
n_unique 152 (109, 219) 386 (324, 426) 145 (88, 246) 155 (111, 237) 155 (111, 230)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop 7 (6, 11) NA (NA, NA) 4 (3, 6) 22 (6, 28) 6 (4, 6)
post_p 0.05 (0, 0.29) NA (NA, NA) 0.97 (0.64, 1) 0.05 (0, 0.34) 0.04 (0, 0.29)
rate 0.113 (0.102, 0.126) 0.094 (0.087, 0.102) 0.078 (0.06, 0.09) 0.112 (0.101, 0.126) 0.113 (0.102, 0.128)
DRD+ graduation 1 0 7 2 0
futility 41 0 2 42 40
max_n 0 0 0 0 0
n 58 (39, 81) 112 (92, 128) 37 (18, 58) 58 (37, 80) 47 (26, 70)
n_unique 53 (35, 74) 102 (84, 118) 33 (17, 53) 53 (33, 73) 43 (24, 65)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop 24 (15, 34) NA (NA, NA) 26 (20, 29) 24 (14, 34) 26 (20, 34)
post_p 0.2 (0.02, 0.67) NA (NA, NA) 0.62 (0.18, 0.95) 0.19 (0.02, 0.68) 0.26 (0.04, 0.71)
rate 0.114 (0.094, 0.141) 0.097 (0.083, 0.113) 0.091 (0.068, 0.125) 0.115 (0.096, 0.143) 0.112 (0.093, 0.146)
TEfus+ graduation 2 0 10 3 3
futility 42 0 3 30 48
max_n 0 0 0 0 0
n 68 (42, 97) 151 (127, 173) 59 (28, 88) 69 (45, 98) 71 (42, 100)
n_unique 62 (39, 89) 138 (117, 158) 55 (26, 80) 64 (40, 90) 66 (39, 92)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (35, 36)
time_stop 20 (15, 35) NA (NA, NA) 16 (12, 28) 21 (14, 34) 20 (11, 32)
post_p 0.27 (0.04, 0.73) NA (NA, NA) 0.72 (0.24, 0.97) 0.27 (0.03, 0.68) 0.24 (0.04, 0.7)
rate 0.113 (0.096, 0.135) 0.1 (0.088, 0.113) 0.092 (0.072, 0.115) 0.112 (0.096, 0.139) 0.114 (0.097, 0.139)
TP53- & AR- graduation 1 0 405 3 1
futility 391 0 2 382 396
max_n 16 0 49 27 11
n 44 (26, 122) 177 (109, 206) 34 (25, 150) 46 (25, 134) 41 (25, 120)
n_unique 40 (23, 114) 165 (98, 193) 32 (24, 141) 42 (23, 127) 36 (23, 111)
time_trial 23 (14, 36) 36 (36, 36) 10 (7, 36) 24 (14, 36) 25 (14, 36)
time_stop 20 (13, 31) NA (NA, NA) 9 (6, 20) 21 (13, 32) 21 (13, 33)
post_p 0.01 (0, 0.15) NA (NA, NA) 1 (0.97, 1) 0.02 (0, 0.12) 0.01 (0, 0.12)
rate 0.115 (0.095, 0.143) 0.075 (0.064, 0.084) 0.041 (0.031, 0.051) 0.114 (0.097, 0.145) 0.116 (0.098, 0.152)
TP53+ graduation 3 0 3 4 9
futility 35 0 29 30 29
max_n 8 0 10 9 12
n 82 (54, 119) 184 (162, 210) 84 (33, 122) 86 (51, 126) 89 (53, 127)
n_unique 76 (49, 111) 170 (148, 194) 76 (31, 114) 79 (47, 117) 81 (49, 118)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop 20 (13, 35) NA (NA, NA) 19 (11, 29) 19 (11, 32) 15 (8, 31)
post_p 0.49 (0.1, 0.9) NA (NA, NA) 0.52 (0.09, 0.89) 0.51 (0.1, 0.88) 0.53 (0.11, 0.9)
rate 0.113 (0.097, 0.138) 0.113 (0.101, 0.124) 0.112 (0.096, 0.137) 0.113 (0.097, 0.135) 0.112 (0.097, 0.135)


By subgroup combinations:
subtype var Carboplatin Control Hormone_therapies Niraparib Taxel_therapies
—- graduation 396 0 439 387 404
futility 0 0 0 0 0
max_n 16 0 49 27 11
n 19 (8, 74) 114 (70, 136) 27 (19, 107) 22 (8, 83) 21 (8, 76)
n_unique 18 (7, 71) 106 (62, 128) 25 (17, 103) 20 (7, 79) 19 (7, 72)
post_p 0.08 (0.01, 0.31) NA (NA, NA) 1 (0.93, 1) 0.07 (0, 0.32) 0.06 (0.01, 0.3)
rate 0.117 (0.09, 0.173) 0.074 (0.064, 0.087) 0.041 (0.03, 0.053) 0.116 (0.09, 0.18) 0.119 (0.093, 0.183)
—+ graduation 403 0 439 389 409
futility 0 0 0 0 0
max_n 16 0 49 27 11
n 6 (2, 17) 20 (12, 28) 4 (2, 14) 6 (2, 19) 7 (3, 17)
n_unique 5 (1, 16) 18 (10, 26) 4 (1, 13) 6 (2, 17) 6 (2, 16)
post_p 0.3 (0.12, 0.61) NA (NA, NA) 0.83 (0.45, 0.98) 0.27 (0.09, 0.57) 0.24 (0.08, 0.52)
rate 0.127 (0.075, 0.328) 0.076 (0.051, 0.11) 0.044 (0.018, 0.096) 0.127 (0.077, 0.342) 0.136 (0.083, 0.299)
–+- graduation 41 0 68 36 45
futility 0 0 0 0 0
max_n 8 0 10 9 12
n 22 (7, 52) 62 (49, 77) 26 (8, 56) 24 (6, 54) 26 (8, 57)
n_unique 20 (6, 50) 57 (45, 72) 24 (7, 52) 22 (5, 50) 23 (7, 54)
post_p 0.43 (0.11, 0.85) NA (NA, NA) 0.46 (0.1, 0.87) 0.42 (0.11, 0.86) 0.45 (0.12, 0.88)
rate 0.12 (0.092, 0.206) 0.112 (0.094, 0.136) 0.118 (0.09, 0.191) 0.118 (0.091, 0.211) 0.117 (0.088, 0.202)
–++ graduation 76 0 79 66 88
futility 0 0 0 0 0
max_n 8 0 10 9 12
n 14 (4, 34) 41 (32, 53) 17 (4, 36) 14 (5, 35) 18 (7, 41)
n_unique 12 (3, 31) 38 (29, 50) 15 (3, 34) 14 (4, 33) 17 (6, 39)
post_p 0.45 (0.15, 0.85) NA (NA, NA) 0.49 (0.15, 0.87) 0.44 (0.14, 0.83) 0.48 (0.13, 0.87)
rate 0.119 (0.085, 0.276) 0.113 (0.09, 0.143) 0.119 (0.082, 0.227) 0.121 (0.086, 0.228) 0.117 (0.089, 0.195)
-+– graduation 401 0 439 394 407
futility 0 0 0 0 0
max_n 16 0 49 26 11
n 8 (3, 20) 19 (11, 27) 2 (0, 11) 8 (3, 19) 7 (2, 17)
n_unique 7 (3, 18) 18 (10, 25) 1 (0, 11) 7 (2, 18) 6 (1, 16)
post_p 0.25 (0.09, 0.58) NA (NA, NA) 0.78 (0.42, 0.96) 0.27 (0.09, 0.58) 0.3 (0.11, 0.62)
rate 0.126 (0.079, 0.281) 0.076 (0.052, 0.11) 0.043 (0, 0.129) 0.127 (0.08, 0.301) 0.126 (0.078, 0.363)
-+-+ graduation 407 0 439 395 412
futility 0 0 0 0 0
max_n 16 0 49 26 11
n 8 (3, 19) 20 (12, 28) 2 (0, 11) 8 (3, 20) 6 (2, 18)
n_unique 7 (3, 17) 18 (11, 26) 2 (0, 11) 7 (3, 18) 5 (2, 17)
post_p 0.26 (0.1, 0.58) NA (NA, NA) 0.75 (0.4, 0.96) 0.25 (0.08, 0.56) 0.3 (0.11, 0.6)
rate 0.122 (0.081, 0.259) 0.074 (0.052, 0.109) 0.049 (0.015, 0.135) 0.129 (0.085, 0.302) 0.125 (0.078, 0.308)
-++- graduation 74 0 77 71 76
futility 0 0 0 0 0
max_n 8 0 10 9 12
n 6 (2, 13) 12 (7, 17) 4 (1, 11) 6 (2, 12) 4 (1, 11)
n_unique 5 (2, 12) 11 (7, 16) 4 (1, 10) 6 (2, 11) 4 (1, 10)
post_p 0.46 (0.2, 0.8) NA (NA, NA) 0.47 (0.22, 0.82) 0.44 (0.21, 0.82) 0.45 (0.23, 0.81)
rate 0.135 (0.074, 0.391) 0.117 (0.073, 0.179) 0.13 (0.063, 0.45) 0.131 (0.071, 0.323) 0.132 (0.066, 0.418)
-+++ graduation 102 0 88 97 113
futility 0 0 0 0 0
max_n 8 0 10 9 12
n 6 (2, 13) 12 (7, 18) 4 (1, 10) 6 (2, 13) 4 (1, 10)
n_unique 5 (2, 12) 11 (6, 16) 4 (1, 9) 5 (2, 12) 4 (1, 9)
post_p 0.44 (0.23, 0.82) NA (NA, NA) 0.47 (0.23, 0.82) 0.44 (0.2, 0.84) 0.46 (0.22, 0.82)
rate 0.139 (0.07, 0.322) 0.118 (0.078, 0.175) 0.129 (0.065, 0.383) 0.137 (0.072, 0.396) 0.132 (0.068, 0.431)
+— graduation 4 0 36 5 7
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 8 (3, 17) 20 (14, 27) 8 (2, 18) 8 (2, 18) 10 (4, 20)
n_unique 7 (3, 16) 18 (12, 25) 7 (2, 17) 7 (2, 16) 9 (3, 19)
post_p 0.48 (0.19, 0.85) NA (NA, NA) 0.48 (0.2, 0.84) 0.44 (0.19, 0.85) 0.45 (0.15, 0.83)
rate 0.12 (0.075, 0.283) 0.113 (0.085, 0.169) 0.125 (0.074, 0.265) 0.125 (0.075, 0.308) 0.124 (0.08, 0.305)
+–+ graduation 48 0 49 36 58
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 6 (2, 15) 16 (10, 22) 6 (2, 15) 6 (2, 15) 8 (3, 17)
n_unique 6 (2, 14) 15 (10, 21) 6 (1, 14) 6 (2, 14) 7 (2, 15)
post_p 0.47 (0.21, 0.83) NA (NA, NA) 0.45 (0.2, 0.82) 0.46 (0.21, 0.83) 0.43 (0.17, 0.85)
rate 0.124 (0.07, 0.343) 0.114 (0.083, 0.162) 0.128 (0.075, 0.334) 0.127 (0.071, 0.392) 0.13 (0.079, 0.321)
+-+- graduation 41 0 68 36 45
futility 0 0 0 0 0
max_n 8 0 10 9 12
n 6 (2, 14) 16 (11, 23) 6 (2, 14) 7 (2, 15) 8 (3, 16)
n_unique 5 (2, 13) 15 (9, 21) 5 (1, 13) 6 (2, 14) 7 (3, 16)
post_p 0.48 (0.21, 0.84) NA (NA, NA) 0.43 (0.2, 0.81) 0.48 (0.22, 0.84) 0.45 (0.19, 0.82)
rate 0.122 (0.071, 0.332) 0.116 (0.081, 0.17) 0.133 (0.073, 0.34) 0.125 (0.07, 0.293) 0.127 (0.081, 0.281)
+-++ graduation 76 0 79 66 88
futility 0 0 0 0 0
max_n 8 0 10 9 12
n 6 (2, 15) 16 (10, 22) 6 (1, 15) 6 (2, 14) 7 (2, 17)
n_unique 6 (2, 14) 14 (10, 20) 5 (1, 13) 6 (2, 14) 7 (2, 16)
post_p 0.49 (0.21, 0.83) NA (NA, NA) 0.44 (0.2, 0.8) 0.48 (0.2, 0.82) 0.45 (0.19, 0.81)
rate 0.122 (0.073, 0.362) 0.113 (0.081, 0.166) 0.127 (0.074, 0.392) 0.122 (0.068, 0.358) 0.128 (0.081, 0.312)
++– graduation 45 0 45 47 47
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 6 (2, 13) 11 (7, 16) 4 (1, 10) 6 (2, 12) 4 (1, 10)
n_unique 6 (2, 12) 10 (6, 15) 4 (1, 9) 5 (2, 11) 4 (1, 10)
post_p 0.49 (0.21, 0.83) NA (NA, NA) 0.46 (0.23, 0.8) 0.45 (0.19, 0.83) 0.46 (0.22, 0.78)
rate 0.123 (0.069, 0.339) 0.116 (0.074, 0.181) 0.13 (0.067, 0.381) 0.133 (0.073, 0.383) 0.129 (0.068, 0.39)
++-+ graduation 77 0 58 73 91
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 6 (2, 13) 11 (7, 17) 4 (1, 10) 6 (2, 13) 4 (1, 11)
n_unique 5 (2, 12) 10 (6, 16) 3 (1, 9) 6 (2, 13) 4 (1, 10)
post_p 0.47 (0.2, 0.82) NA (NA, NA) 0.46 (0.22, 0.8) 0.47 (0.21, 0.85) 0.46 (0.23, 0.82)
rate 0.128 (0.074, 0.373) 0.116 (0.075, 0.177) 0.132 (0.07, 0.493) 0.125 (0.07, 0.392) 0.132 (0.07, 0.428)
+++- graduation 74 0 77 71 76
futility 0 0 0 0 0
max_n 8 0 10 9 12
n 6 (2, 12) 11 (7, 17) 4 (1, 10) 6 (2, 13) 4 (1, 11)
n_unique 5 (2, 12) 10 (6, 16) 4 (1, 9) 5 (2, 12) 4 (1, 10)
post_p 0.45 (0.2, 0.83) NA (NA, NA) 0.48 (0.21, 0.82) 0.44 (0.2, 0.81) 0.46 (0.24, 0.83)
rate 0.126 (0.07, 0.333) 0.111 (0.074, 0.176) 0.124 (0.065, 0.421) 0.131 (0.074, 0.388) 0.127 (0.063, 0.503)
++++ graduation 102 0 88 97 113
futility 0 0 0 0 0
max_n 8 0 10 9 12
n 6 (2, 13) 12 (7, 17) 4 (1, 11) 6 (2, 12) 4 (1, 11)
n_unique 5 (2, 12) 11 (7, 16) 4 (1, 10) 5 (2, 11) 4 (1, 10)
post_p 0.43 (0.19, 0.85) NA (NA, NA) 0.44 (0.23, 0.81) 0.46 (0.2, 0.81) 0.47 (0.23, 0.81)
rate 0.132 (0.07, 0.359) 0.115 (0.073, 0.175) 0.131 (0.065, 0.438) 0.125 (0.071, 0.382) 0.127 (0.062, 0.422)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 35 4 2 2
time_stop 4 (3, 7) 6 (5, 7) 6 (6, 7) 6 (5, 8)
n_trt 29 (26, 49) 38 (28, 43) 28 (26, 30) 31 (28, 34)
n_control 49 (40, 71) 70 (52, 78) 76 (68, 84) 67 (56, 78)
post_p 0.94 (0.88, 0.98) 0.92 (0.9, 0.95) 0.98 (0.98, 0.98) 0.91 (0.88, 0.95)
order 1 (1, 1) 1 (1, 1) 1.5 (1.1, 1.9) 1 (1, 1)
TP53- & AR- count 405 1 1 3
time_stop 9 (6, 21) 11 (11, 11) 8 (8, 8) 13 (10, 15)
n_trt 33 (26, 79) 27 (27, 27) 25 (25, 25) 26 (25, 48)
n_control 41 (28, 104) 37 (37, 37) 37 (37, 37) 58 (39, 79)
post_p 0.95 (0.87, 1) 0.96 (0.96, 0.96) 0.85 (0.85, 0.85) 0.9 (0.88, 0.95)
order 1 (1, 1) 1 (1, 1) 2 (2, 2) 2 (1.2, 2)
TP53+ count 3 9 3 4
time_stop 12 (10, 14) 9 (7, 13) 11 (9, 13) 16 (10, 20)
n_trt 42 (30, 46) 29 (26, 40) 33 (28, 40) 40 (29, 52)
n_control 44 (35, 70) 42 (31, 71) 57 (43, 59) 70 (47, 90)
post_p 0.94 (0.94, 0.97) 0.96 (0.91, 0.98) 0.97 (0.89, 0.99) 0.98 (0.94, 1)
order 2 (1.2, 2) 1 (1, 2.2) 2 (1.2, 2) 1.5 (1, 2)
DRD+ count 7 1 2
time_stop 26 (20, 30) 10 (10, 10) 12 (9, 14)
n_trt 26 (25, 34) 25 (25, 25) 31 (27, 35)
n_control 80 (55, 86) 29 (29, 29) 36 (30, 42)
post_p 0.95 (0.93, 0.99) 0.92 (0.92, 0.92) 0.9 (0.88, 0.91)
order 2 (2, 2.4) 2 (2, 2) 1 (1, 1)
TEfus+ count 10 3 2 3
time_stop 15 (12, 23) 11 (8, 13) 12 (10, 14) 12 (11, 13)
n_trt 28 (25, 36) 25 (25, 35) 28 (27, 29) 29 (28, 29)
n_control 56 (43, 85) 46 (30, 54) 58 (47, 70) 45 (39, 50)
post_p 0.98 (0.93, 1) 0.94 (0.89, 0.94) 0.96 (0.96, 0.96) 0.92 (0.9, 0.92)
order 2 (2, 2.1) 2 (1.2, 2) 2.5 (2.1, 2.9) 2 (2, 2)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 1 3 2 3
time_stop 3 (3, 3) 5 (3, 6) 10 (8, 12) 28 (23, 28)
n_trt 26 (26, 26) 28 (26, 38) 44 (29, 58) 107 (85, 167)
n_control 31 (31, 31) 56 (38, 63) 105 (84, 126) 332 (268, 347)
post_p 0.15 (0.15, 0.15) 0.08 (0.06, 0.17) 0.02 (0.01, 0.04) 0 (0, 0.01)
order 1 (1, 1) 1 (1, 1) 1 (1, 1) 4 (2.4, 6.4)
TP53- & AR- count 2 396 391 382
time_stop 6 (6, 7) 21 (13, 33) 20 (13, 31) 21 (13, 32)
n_trt 28 (26, 29) 36 (25, 94) 38 (26, 87) 35 (25, 96)
n_control 33 (32, 34) 107 (57, 178) 101 (59, 165) 104 (58, 174)
post_p 0.15 (0.13, 0.18) 0.05 (0, 0.2) 0.06 (0, 0.2) 0.05 (0, 0.18)
order 1 (1, 1) 2 (1, 4) 2 (1, 3) 2 (1, 4)
TP53+ count 29 29 35 30
time_stop 20 (11, 29) 22 (9, 33) 20 (13, 35) 19 (12, 33)
n_trt 34 (27, 62) 37 (26, 76) 38 (26, 61) 36 (26, 67)
n_control 95 (40, 148) 107 (44, 164) 101 (60, 181) 94 (53, 170)
post_p 0.04 (0, 0.19) 0.06 (0, 0.16) 0.05 (0.01, 0.14) 0.05 (0.01, 0.15)
order 2 (1, 4) 2 (1, 5) 2 (1, 5) 3 (1, 5)
DRD+ count 2 40 41 42
time_stop 26 (24, 27) 26 (20, 34) 24 (16, 34) 26 (14, 34)
n_trt 26 (25, 27) 29 (25, 44) 39 (27, 54) 36 (26, 52)
n_control 82 (78, 86) 78 (55, 114) 70 (45, 105) 78 (42, 106)
post_p 0.04 (0.02, 0.07) 0.04 (0, 0.17) 0.04 (0.01, 0.14) 0.04 (0.01, 0.1)
order 3.5 (2.3, 4.7) 4 (1, 5) 3 (2, 5) 3 (1, 5)
TEfus+ count 3 48 42 30
time_stop 26 (19, 28) 20 (12, 32) 20 (15, 35) 22 (16, 34)
n_trt 29 (27, 36) 38 (26, 63) 36 (26, 58) 42 (28, 60)
n_control 121 (72, 126) 81 (41, 138) 90 (56, 148) 88 (54, 140)
post_p 0.12 (0.05, 0.14) 0.04 (0.01, 0.15) 0.05 (0.01, 0.12) 0.05 (0.01, 0.19)
order 3 (1.4, 3.8) 2.5 (1, 4.3) 3 (1, 5) 3 (1, 6.1)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Carboplatin count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7)
n 4 (3, 4) 1 (1, 1) 3 (1, 5) 0 (0, 0) 4 (4, 4) 0 (0, 1) 2 (2, 3) 2 (2, 2) 0 (0, 1) 2 (1, 4) 2 (2, 3) 1 (1, 1) 2 (2, 2) 1 (0, 2) 1 (0, 2) 2 (1, 2)
post_p 0.59 (0.57, 0.6) 0.56 (0.56, 0.56) 0.59 (0.54, 0.64) NA (NA, NA) 0.72 (0.71, 0.73) 0.57 (0.57, 0.57) 0.52 (0.52, 0.52) 0.56 (0.53, 0.58) 0.5 (0.5, 0.5) 0.53 (0.52, 0.53) 0.63 (0.58, 0.68) 0.51 (0.5, 0.52) 0.77 (0.76, 0.78) 0.51 (0.51, 0.51) 0.76 (0.76, 0.76) 0.63 (0.58, 0.68)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.037 (0.007, 0.066) NA (NA, NA) 0.031 (0.006, 0.056) 0 (0, 0) 0.043 (0.009, 0.078) 0.152 (0.03, 0.273) 0 (0, 0) 0.074 (0.015, 0.133) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Hormone_therapies count 35 35 35 35 35 35 35 35 35 35 35 35 35 35 35 35
time 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7) 4 (3, 7)
n 15 (12, 22) 2 (1, 6) 6 (3, 10) 2 (0, 7) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 1 (0, 2) 1 (0, 3) 0 (0, 2) 0 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1)
post_p 0.76 (0.64, 0.9) 0.63 (0.54, 0.71) 0.65 (0.54, 0.77) 0.59 (0.52, 0.73) 0.54 (0.51, 0.58) 0.54 (0.53, 0.57) 0.54 (0.51, 0.56) 0.51 (0.51, 0.61) 0.6 (0.53, 0.69) 0.57 (0.51, 0.69) 0.58 (0.51, 0.64) 0.59 (0.52, 0.67) NA (NA, NA) 0.52 (0.51, 0.52) 0.52 (0.51, 0.55) 0.52 (0.51, 0.54)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.023 (0, 0.048) 0 (0, 0.025) 0.05 (0, 0.134) 0 (0, 0.083) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.094) 0 (0, 0.108) 0 (0, 0.54) 0 (0, 0) 0 (0, 0) 0 (0, 0.205) 0 (0, 0)
Niraparib count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8)
n 2 (1, 3) 0 (0, 1) 6 (4, 8) 1 (1, 1) 2 (1, 3) 2 (2, 3) 3 (3, 3) 2 (2, 2) 2 (1, 3) 0 (0, 0) 0 (0, 1) 0 (0, 1) 2 (1, 3) 3 (2, 4) 2 (1, 2) 2 (2, 3)
post_p 0.58 (0.55, 0.6) 0.56 (0.56, 0.56) 0.51 (0.51, 0.52) 0.54 (0.52, 0.56) 0.62 (0.57, 0.67) 0.63 (0.59, 0.66) 0.73 (0.71, 0.75) 0.6 (0.56, 0.64) 0.56 (0.54, 0.59) NA (NA, NA) 0.51 (0.51, 0.51) 0.51 (0.51, 0.51) 0.63 (0.59, 0.66) 0.62 (0.62, 0.62) 0.57 (0.54, 0.59) 0.65 (0.6, 0.71)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.096 (0.083, 0.108) 0 (0, 0) 0 (0, 0) 0.057 (0.011, 0.102) 0.061 (0.012, 0.111) 0.065 (0.013, 0.117) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.096 (0.019, 0.173) 0.078 (0.016, 0.14) 0.024 (0.005, 0.043)
Taxel_therapies count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7)
n 4 (2, 8) 2 (0, 4) 6 (3, 9) 6 (4, 7) 0 (0, 2) 0 (0, 2) 0 (0, 1) 0 (0, 1) 6 (4, 6) 3 (2, 3) 3 (2, 4) 4 (2, 5) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1)
post_p 0.56 (0.54, 0.65) 0.59 (0.52, 0.66) 0.74 (0.66, 0.89) 0.66 (0.56, 0.72) 0.54 (0.52, 0.55) 0.57 (0.55, 0.58) 0.59 (0.59, 0.59) 0.51 (0.51, 0.51) 0.63 (0.54, 0.66) 0.64 (0.53, 0.75) 0.73 (0.61, 0.81) 0.59 (0.52, 0.73) 0.56 (0.56, 0.56) 0.51 (0.51, 0.51) NA (NA, NA) 0.52 (0.52, 0.52)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.023 (0, 0.088) 0 (0, 0) 0 (0, 0.03) 0.019 (0, 0.067) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.096 (0.056, 0.172) 0.108 (0.032, 0.138) 0 (0, 0.033) 0.041 (0, 0.113) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0)
DRD+ Carboplatin count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 9 (9, 9) 4 (4, 4) 2 (2, 2) 1 (1, 1) 5 (5, 5) 3 (3, 3) 0 (0, 0) 1 (1, 1)
post_p 0.82 (0.82, 0.82) 0.71 (0.71, 0.71) 0.58 (0.58, 0.58) 0.51 (0.51, 0.51) 0.88 (0.88, 0.88) 0.7 (0.7, 0.7) NA (NA, NA) 0.55 (0.55, 0.55)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.08 (0.08, 0.08) 0.049 (0.049, 0.049) 0 (0, 0) 0 (0, 0) 0.085 (0.085, 0.085) 0.057 (0.057, 0.057) NA (NA, NA) 0 (0, 0)
Hormone_therapies count 7 7 7 7 7 7 7 7
time 26 (20, 30) 26 (20, 30) 26 (20, 30) 26 (20, 30) 26 (20, 30) 26 (20, 30) 26 (20, 30) 26 (20, 30)
n 1 (0, 4) 1 (1, 8) 4 (3, 8) 3 (3, 7) 2 (2, 3) 3 (1, 4) 4 (1, 5) 4 (3, 9)
post_p 0.74 (0.64, 0.76) 0.84 (0.64, 0.91) 0.72 (0.62, 0.87) 0.73 (0.64, 0.84) 0.6 (0.52, 0.74) 0.65 (0.52, 0.76) 0.71 (0.6, 0.84) 0.71 (0.52, 0.82)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.03 (0.007, 0.052) 0 (0, 0.057) 0.063 (0.036, 0.116) 0.057 (0.019, 0.097) 0.055 (0, 0.083) 0.09 (0.016, 0.164) 0.065 (0.047, 0.087) 0.065 (0.028, 0.108)
Niraparib count 2 2 2 2 2 2 2 2
time 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14) 12 (9, 14)
n 4 (3, 4) 7 (5, 9) 5 (4, 6) 2 (2, 3) 5 (5, 5) 0 (0, 1) 4 (4, 4) 4 (3, 4)
post_p 0.6 (0.6, 0.62) 0.72 (0.7, 0.74) 0.84 (0.76, 0.92) 0.55 (0.51, 0.59) 0.68 (0.63, 0.73) 0.52 (0.52, 0.52) 0.52 (0.52, 0.52) 0.59 (0.52, 0.66)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.042 (0.008, 0.076) 0.077 (0.07, 0.083) 0.012 (0.002, 0.021) 0.082 (0.016, 0.147) 0.04 (0.008, 0.072) 0.112 (0.112, 0.112) 0.098 (0.075, 0.121) 0.157 (0.07, 0.244)
TEfus+ Carboplatin count 2 2 2 2 2 2 2 2
time 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14)
n 2 (1, 2) 4 (2, 5) 3 (3, 3) 4 (3, 5) 4 (3, 6) 2 (1, 4) 6 (3, 8) 4 (3, 4)
post_p 0.58 (0.52, 0.64) 0.58 (0.56, 0.59) 0.6 (0.53, 0.66) 0.72 (0.67, 0.77) 0.76 (0.74, 0.79) 0.69 (0.66, 0.72) 0.81 (0.81, 0.81) 0.65 (0.65, 0.66)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.114 (0.113, 0.115) 0.085 (0.069, 0.102) 0.018 (0.004, 0.032) 0.026 (0.005, 0.048) 0.022 (0.004, 0.039) 0.13 (0.127, 0.134) 0.048 (0.041, 0.054)
Hormone_therapies count 10 10 10 10 10 10 10 10
time 15 (12, 23) 15 (12, 23) 15 (12, 23) 15 (12, 23) 15 (12, 23) 15 (12, 23) 15 (12, 23) 15 (12, 23)
n 5 (3, 6) 6 (5, 14) 2 (1, 4) 2 (1, 4) 2 (1, 7) 5 (2, 8) 2 (0, 4) 1 (0, 4)
post_p 0.82 (0.72, 0.9) 0.74 (0.57, 0.88) 0.73 (0.6, 0.9) 0.64 (0.5, 0.87) 0.65 (0.55, 0.78) 0.64 (0.53, 0.76) 0.57 (0.52, 0.72) 0.61 (0.56, 0.75)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.023 (0, 0.057) 0.073 (0.051, 0.109) 0 (0, 0.045) 0 (0, 0.075) 0.082 (0, 0.107) 0.076 (0, 0.114) 0.072 (0, 0.11) 0 (0, 0.074)
Niraparib count 3 3 3 3 3 3 3 3
time 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13)
n 1 (0, 3) 8 (6, 9) 4 (4, 7) 3 (1, 5) 2 (1, 3) 2 (1, 4) 3 (2, 5) 4 (4, 4)
post_p 0.52 (0.52, 0.53) 0.73 (0.59, 0.86) 0.62 (0.56, 0.79) 0.56 (0.51, 0.62) 0.64 (0.54, 0.66) 0.62 (0.58, 0.65) 0.67 (0.55, 0.67) 0.74 (0.71, 0.77)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0.054 (0.034, 0.072) 0.048 (0.047, 0.056) 0.06 (0.012, 0.125) 0 (0, 0) 0 (0, 0.037) 0.101 (0.073, 0.285) 0.08 (0.016, 0.131)
Taxel_therapies count 3 3 3 3 3 3 3 3
time 11 (8, 13) 11 (8, 13) 11 (8, 13) 11 (8, 13) 11 (8, 13) 11 (8, 13) 11 (8, 13) 11 (8, 13)
n 2 (0, 3) 15 (12, 17) 1 (0, 4) 1 (0, 2) 3 (2, 5) 4 (2, 10) 0 (0, 0) 0 (0, 2)
post_p 0.54 (0.51, 0.56) 0.71 (0.7, 0.83) 0.63 (0.56, 0.7) 0.59 (0.52, 0.66) 0.71 (0.63, 0.71) 0.88 (0.75, 0.93) NA (NA, NA) 0.6 (0.6, 0.6)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.045 (0.009, 0.08) 0.063 (0.062, 0.072) 0 (0, 0) 0.032 (0.006, 0.058) 0.055 (0.011, 0.08) 0.068 (0.014, 0.076) NA (NA, NA) 0 (0, 0)
TP53- & AR- Carboplatin count 1 1 1 1
time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
n 10 (10, 10) 4 (4, 4) 7 (7, 7) 4 (4, 4)
post_p 0.73 (0.73, 0.73) 0.58 (0.58, 0.58) 0.77 (0.77, 0.77) 0.55 (0.55, 0.55)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.048 (0.048, 0.048) 0 (0, 0) 0.033 (0.033, 0.033) 0.247 (0.247, 0.247)
Hormone_therapies count 405 405 405 405
time 9 (6, 21) 9 (6, 21) 9 (6, 21) 9 (6, 21)
n 26 (20, 58) 4 (2, 11) 1 (0, 7) 2 (0, 6)
post_p 0.89 (0.75, 1) 0.71 (0.53, 0.85) 0.59 (0.51, 0.85) 0.6 (0.52, 0.79)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.038 (0.015, 0.055) 0.023 (0, 0.075) 0 (0, 0.059) 0 (0, 0.07)
Niraparib count 3 3 3 3
time 13 (10, 15) 13 (10, 15) 13 (10, 15) 13 (10, 15)
n 14 (13, 24) 4 (2, 6) 9 (5, 10) 4 (2, 9)
post_p 0.78 (0.75, 0.84) 0.56 (0.53, 0.85) 0.78 (0.62, 0.9) 0.58 (0.55, 0.7)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.043 (0.009, 0.051) 0.041 (0.008, 0.042) 0.044 (0.037, 0.05) 0.043 (0.009, 0.058)
Taxel_therapies count 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 16 (16, 16) 4 (4, 4) 3 (3, 3) 4 (4, 4)
post_p 0.76 (0.76, 0.76) 0.79 (0.79, 0.79) 0.72 (0.72, 0.72) 0.64 (0.64, 0.64)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.078 (0.078, 0.078) 0 (0, 0) 0 (0, 0) 0.056 (0.056, 0.056)
TP53+ Carboplatin count 3 3 3 3 3 3 3 3
time 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13) 11 (9, 13)
n 14 (13, 15) 5 (2, 9) 2 (0, 3) 3 (2, 4) 2 (2, 4) 1 (1, 3) 2 (0, 4) 4 (3, 4)
post_p 0.81 (0.77, 0.89) 0.53 (0.53, 0.8) 0.63 (0.6, 0.65) 0.66 (0.57, 0.7) 0.58 (0.58, 0.62) 0.64 (0.53, 0.64) 0.59 (0.56, 0.63) 0.69 (0.63, 0.73)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.043 (0.04, 0.052) 0.091 (0.018, 0.095) 0.222 (0.112, 0.332) 0 (0, 0.09) 0.091 (0.018, 0.132) 0 (0, 0.06) 0.088 (0.068, 0.108) 0.104 (0.07, 0.153)
Hormone_therapies count 3 3 3 3 3 3 3 3
time 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14)
n 18 (13, 23) 5 (5, 8) 2 (0, 3) 2 (1, 3) 5 (4, 7) 5 (1, 5) 2 (0, 4) 0 (0, 0)
post_p 0.88 (0.81, 0.9) 0.72 (0.61, 0.81) 0.61 (0.57, 0.65) 0.63 (0.63, 0.67) 0.75 (0.57, 0.81) 0.54 (0.54, 0.54) 0.62 (0.56, 0.67) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.056 (0.052, 0.078) 0.084 (0.064, 0.085) 0.067 (0.013, 0.121) 0 (0, 0.06) 0.1 (0.046, 0.139) 0.065 (0.013, 0.116) 0.027 (0.005, 0.049) NA (NA, NA)
Niraparib count 4 4 4 4 4 4 4 4
time 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20) 16 (10, 20)
n 16 (11, 22) 4 (1, 7) 3 (2, 5) 4 (1, 10) 2 (0, 3) 4 (2, 5) 3 (2, 4) 3 (1, 4)
post_p 0.9 (0.8, 0.94) 0.72 (0.58, 0.77) 0.72 (0.55, 0.79) 0.75 (0.56, 0.92) 0.67 (0.64, 0.7) 0.75 (0.61, 0.79) 0.7 (0.59, 0.82) 0.7 (0.56, 0.86)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.053 (0.035, 0.067) 0.086 (0.063, 0.111) 0.107 (0.076, 0.135) 0.081 (0.018, 0.109) 0.046 (0.009, 0.082) 0.065 (0.014, 0.089) 0.092 (0.022, 0.113) 0.088 (0.018, 0.122)
Taxel_therapies count 9 9 9 9 9 9 9 9
time 9 (7, 13) 9 (7, 13) 9 (7, 13) 9 (7, 13) 9 (7, 13) 9 (7, 13) 9 (7, 13) 9 (7, 13)
n 9 (6, 13) 11 (7, 15) 0 (0, 2) 1 (0, 3) 3 (2, 5) 3 (2, 5) 1 (0, 3) 1 (0, 3)
post_p 0.76 (0.69, 0.86) 0.81 (0.67, 0.88) 0.65 (0.56, 0.75) 0.57 (0.52, 0.63) 0.57 (0.53, 0.85) 0.55 (0.51, 0.7) 0.59 (0.51, 0.72) 0.62 (0.53, 0.63)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.078 (0.054, 0.116) 0.05 (0.03, 0.093) 0 (0, 0) 0 (0, 0.039) 0.081 (0, 0.142) 0.062 (0, 0.092) 0 (0, 0.078) 0 (0, 0.034)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Carboplatin count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12)
n 6 (4, 8) 0 (0, 0) 6 (4, 8) 4 (3, 6) 5 (5, 5) 6 (5, 6) 1 (0, 2) 1 (0, 2) 2 (1, 3) 2 (1, 2) 2 (1, 3) 0 (0, 0) 2 (1, 2) 2 (0, 3) 2 (1, 4) 4 (1, 6)
post_p 0.29 (0.2, 0.38) NA (NA, NA) 0.34 (0.27, 0.41) 0.4 (0.37, 0.42) 0.22 (0.12, 0.33) 0.45 (0.41, 0.48) 0.46 (0.46, 0.46) 0.49 (0.49, 0.49) 0.45 (0.43, 0.48) 0.39 (0.31, 0.47) 0.35 (0.24, 0.46) NA (NA, NA) 0.34 (0.31, 0.37) 0.12 (0.12, 0.12) 0.33 (0.27, 0.39) 0.46 (0.46, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.161 (0.153, 0.169) NA (NA, NA) 0.227 (0.154, 0.299) 0.203 (0.154, 0.253) 0.189 (0.09, 0.288) 0.112 (0.09, 0.135) 0.08 (0.08, 0.08) 0.095 (0.095, 0.095) 0.089 (0.018, 0.161) 0.171 (0.034, 0.307) 0.25 (0.218, 0.282) NA (NA, NA) 0.209 (0.206, 0.212) 0.551 (0.551, 0.551) 0.245 (0.131, 0.359) 0.041 (0.041, 0.041)
Hormone_therapies count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3) 3 (3, 3)
n 13 (13, 13) 2 (2, 2) 6 (6, 6) 3 (3, 3) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.2 (0.2, 0.2) 0.34 (0.34, 0.34) 0.36 (0.36, 0.36) 0.24 (0.24, 0.24) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.102 (0.102, 0.102) 0.292 (0.292, 0.292) 0.078 (0.078, 0.078) 0.206 (0.206, 0.206) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Niraparib count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
time 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28) 28 (23, 28)
n 22 (13, 70) 5 (2, 15) 10 (8, 33) 4 (2, 17) 10 (4, 18) 2 (1, 8) 3 (3, 7) 1 (1, 2) 2 (1, 4) 4 (1, 6) 3 (2, 7) 4 (2, 5) 2 (2, 4) 3 (3, 5) 2 (2, 4) 2 (2, 6)
post_p 0.06 (0.05, 0.37) 0.39 (0.38, 0.39) 0.14 (0.11, 0.43) 0.44 (0.21, 0.47) 0.33 (0.17, 0.4) 0.32 (0.32, 0.34) 0.24 (0.19, 0.34) 0.37 (0.32, 0.38) 0.41 (0.28, 0.42) 0.36 (0.35, 0.37) 0.3 (0.27, 0.45) 0.35 (0.27, 0.46) 0.19 (0.18, 0.2) 0.28 (0.24, 0.3) 0.18 (0.14, 0.43) 0.34 (0.24, 0.42)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.106 (0.103, 0.185) 0.153 (0.113, 2.178) 0.23 (0.138, 0.234) 0.122 (0.106, 1.745) 0.142 (0.105, 0.184) 0.2 (0.111, 4.306) 0.296 (0.172, 0.441) 0.326 (0.234, 0.335) 0.287 (0.183, 0.304) 0.144 (0.14, 0.148) 0.148 (0.122, 0.389) 0.178 (0.155, 0.39) 0.418 (0.226, 0.877) 0.197 (0.121, 0.394) 0.218 (0.139, 0.299) 0.267 (0.181, 0.485)
Taxel_therapies count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
time 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6)
n 6 (5, 8) 3 (3, 4) 3 (2, 10) 6 (5, 8) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 1) 3 (3, 4) 1 (0, 1) 1 (0, 4) 4 (1, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.44 (0.28, 0.46) 0.45 (0.45, 0.49) 0.48 (0.16, 0.48) 0.37 (0.33, 0.47) 0.24 (0.24, 0.24) NA (NA, NA) NA (NA, NA) 0.48 (0.48, 0.48) 0.46 (0.46, 0.48) 0.39 (0.31, 0.47) 0.43 (0.43, 0.43) 0.35 (0.28, 0.41) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.114 (0.083, 0.306) 0.185 (0.037, 0.192) 0.141 (0.028, 0.234) 0.128 (0.127, 0.131) 1.07 (1.07, 1.07) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0.124 (0.025, 0.211) 0.143 (0.029, 0.258) 0.712 (0.187, 1.236) 0.251 (0.216, 0.285) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
DRD+ Carboplatin count 41 41 41 41 41 41 41 41
time 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34)
n 7 (2, 14) 7 (3, 14) 3 (2, 7) 3 (1, 6) 4 (1, 8) 3 (1, 8) 5 (2, 8) 4 (1, 7)
post_p 0.38 (0.14, 0.46) 0.3 (0.12, 0.43) 0.33 (0.18, 0.46) 0.37 (0.22, 0.45) 0.35 (0.23, 0.47) 0.38 (0.19, 0.47) 0.38 (0.13, 0.48) 0.36 (0.15, 0.46)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.129 (0.087, 0.328) 0.13 (0.089, 0.243) 0.2 (0.104, 1.192) 0.203 (0.104, 0.4) 0.161 (0.107, 0.608) 0.149 (0.102, 0.597) 0.154 (0.101, 0.278) 0.195 (0.091, 0.593)
Hormone_therapies count 2 2 2 2 2 2 2 2
time 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27) 26 (24, 27)
n 0 (0, 1) 2 (2, 2) 4 (3, 4) 7 (6, 8) 3 (2, 4) 1 (1, 1) 2 (1, 4) 6 (5, 8)
post_p 0.42 (0.42, 0.42) 0.43 (0.41, 0.44) 0.24 (0.2, 0.28) 0.28 (0.22, 0.35) 0.27 (0.27, 0.28) 0.43 (0.38, 0.48) 0.27 (0.22, 0.32) 0.42 (0.35, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.123 (0.123, 0.123) 0.11 (0.108, 0.112) 0.241 (0.21, 0.272) 0.116 (0.105, 0.128) 0.362 (0.305, 0.419) 0.423 (0.246, 0.6) 5.716 (1.253, 10.18) 0.124 (0.079, 0.17)
Niraparib count 42 42 42 42 42 42 42 42
time 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34) 26 (14, 34)
n 5 (2, 14) 6 (3, 18) 4 (1, 9) 3 (1, 7) 4 (1, 6) 4 (1, 8) 4 (2, 6) 4 (2, 8)
post_p 0.29 (0.13, 0.42) 0.29 (0.13, 0.47) 0.38 (0.19, 0.46) 0.32 (0.18, 0.48) 0.33 (0.21, 0.44) 0.34 (0.2, 0.46) 0.36 (0.18, 0.48) 0.38 (0.2, 0.48)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.128 (0.088, 0.491) 0.134 (0.088, 0.374) 0.2 (0.117, 0.683) 0.247 (0.108, 1.097) 0.174 (0.115, 0.344) 0.187 (0.102, 0.662) 0.183 (0.091, 0.489) 0.161 (0.107, 0.372)
Taxel_therapies count 40 40 40 40 40 40 40 40
time 26 (20, 34) 26 (20, 34) 26 (20, 34) 26 (20, 34) 26 (20, 34) 26 (20, 34) 26 (20, 34) 26 (20, 34)
n 6 (2, 17) 5 (2, 10) 2 (1, 5) 2 (0, 5) 4 (1, 8) 3 (1, 6) 2 (1, 8) 2 (1, 5)
post_p 0.32 (0.19, 0.45) 0.31 (0.17, 0.45) 0.35 (0.18, 0.46) 0.34 (0.21, 0.48) 0.36 (0.19, 0.47) 0.38 (0.28, 0.48) 0.36 (0.25, 0.48) 0.38 (0.26, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.124 (0.088, 0.226) 0.129 (0.087, 0.253) 0.204 (0.108, 0.612) 0.243 (0.125, 1.44) 0.187 (0.133, 0.446) 0.164 (0.106, 0.534) 0.168 (0.109, 0.709) 0.217 (0.117, 0.516)
TEfus+ Carboplatin count 42 42 42 42 42 42 42 42
time 20 (15, 35) 20 (15, 35) 20 (15, 35) 20 (15, 35) 20 (15, 35) 20 (15, 35) 20 (15, 35) 20 (15, 35)
n 4 (1, 9) 6 (4, 16) 6 (2, 11) 4 (1, 6) 3 (1, 7) 3 (1, 8) 3 (1, 7) 3 (1, 7)
post_p 0.3 (0.18, 0.45) 0.34 (0.16, 0.47) 0.35 (0.14, 0.47) 0.35 (0.19, 0.47) 0.37 (0.24, 0.46) 0.35 (0.2, 0.45) 0.36 (0.23, 0.48) 0.37 (0.17, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.151 (0.076, 0.416) 0.157 (0.107, 0.311) 0.126 (0.086, 0.255) 0.155 (0.115, 0.539) 0.168 (0.096, 0.699) 0.185 (0.119, 0.786) 0.181 (0.108, 0.615) 0.173 (0.105, 0.318)
Hormone_therapies count 3 3 3 3 3 3 3 3
time 26 (19, 28) 26 (19, 28) 26 (19, 28) 26 (19, 28) 26 (19, 28) 26 (19, 28) 26 (19, 28) 26 (19, 28)
n 4 (2, 4) 9 (5, 18) 1 (0, 2) 2 (1, 2) 4 (3, 8) 3 (2, 5) 4 (3, 4) 2 (1, 4)
post_p 0.36 (0.35, 0.4) 0.22 (0.18, 0.39) 0.44 (0.39, 0.49) 0.34 (0.25, 0.42) 0.38 (0.18, 0.46) 0.46 (0.25, 0.47) 0.42 (0.28, 0.43) 0.36 (0.31, 0.44)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.124 (0.091, 0.141) 0.153 (0.107, 0.333) 0.12 (0.103, 0.137) 0.827 (0.387, 0.924) 0.169 (0.143, 0.272) 0.211 (0.156, 0.542) 0.151 (0.11, 0.227) 0.166 (0.11, 3.035)
Niraparib count 30 30 30 30 30 30 30 30
time 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34) 22 (16, 34)
n 4 (1, 14) 8 (4, 22) 5 (3, 10) 3 (1, 7) 3 (1, 6) 4 (2, 8) 4 (1, 8) 4 (1, 8)
post_p 0.37 (0.13, 0.45) 0.38 (0.15, 0.48) 0.25 (0.13, 0.46) 0.38 (0.18, 0.48) 0.37 (0.22, 0.47) 0.4 (0.19, 0.49) 0.33 (0.16, 0.49) 0.34 (0.22, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.146 (0.085, 0.747) 0.14 (0.102, 0.285) 0.155 (0.095, 0.413) 0.176 (0.11, 0.449) 0.206 (0.118, 0.654) 0.171 (0.095, 0.338) 0.136 (0.091, 1.132) 0.164 (0.096, 0.579)
Taxel_therapies count 48 48 48 48 48 48 48 48
time 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32)
n 4 (2, 12) 10 (5, 21) 4 (1, 9) 2 (0, 5) 5 (3, 10) 5 (2, 10) 2 (0, 7) 2 (0, 4)
post_p 0.31 (0.13, 0.45) 0.32 (0.1, 0.47) 0.33 (0.12, 0.45) 0.35 (0.25, 0.48) 0.39 (0.23, 0.48) 0.34 (0.16, 0.47) 0.35 (0.24, 0.47) 0.35 (0.2, 0.47)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.161 (0.077, 0.337) 0.146 (0.111, 0.238) 0.164 (0.106, 0.568) 0.188 (0.111, 1.131) 0.137 (0.104, 0.346) 0.15 (0.101, 0.458) 0.19 (0.105, 0.643) 0.195 (0.079, 0.768)
TP53- & AR- Carboplatin count 391 391 391 391
time 20 (13, 31) 20 (13, 31) 20 (13, 31) 20 (13, 31)
n 18 (8, 56) 5 (1, 14) 7 (3, 15) 7 (3, 15)
post_p 0.18 (0.03, 0.45) 0.34 (0.16, 0.48) 0.33 (0.13, 0.47) 0.35 (0.13, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.115 (0.084, 0.182) 0.132 (0.081, 0.383) 0.126 (0.083, 0.309) 0.126 (0.081, 0.274)
Hormone_therapies count 2 2 2 2
time 6 (6, 7) 6 (6, 7) 6 (6, 7) 6 (6, 7)
n 24 (22, 25) 2 (2, 3) 0 (0, 1) 1 (0, 2)
post_p 0.4 (0.36, 0.45) 0.12 (0.05, 0.19) 0.49 (0.49, 0.49) 0.19 (0.19, 0.19)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.071 (0.056, 0.085) 0.766 (0.7, 0.832) 0 (0, 0) 0.177 (0.177, 0.177)
Niraparib count 382 382 382 382
time 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32)
n 18 (8, 59) 5 (2, 15) 7 (2, 15) 7 (3, 16)
post_p 0.18 (0.03, 0.45) 0.33 (0.13, 0.47) 0.33 (0.1, 0.48) 0.33 (0.13, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.115 (0.083, 0.19) 0.138 (0.082, 0.428) 0.132 (0.088, 0.34) 0.129 (0.081, 0.34)
Taxel_therapies count 396 396 396 396
time 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33)
n 19 (8, 59) 6 (3, 16) 6 (2, 15) 5 (2, 14)
post_p 0.16 (0.02, 0.41) 0.28 (0.1, 0.46) 0.35 (0.15, 0.48) 0.35 (0.17, 0.48)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.117 (0.086, 0.197) 0.137 (0.086, 0.317) 0.132 (0.079, 0.428) 0.127 (0.08, 0.39)
TP53+ Carboplatin count 35 35 35 35 35 35 35 35
time 20 (13, 35) 20 (13, 35) 20 (13, 35) 20 (13, 35) 20 (13, 35) 20 (13, 35) 20 (13, 35) 20 (13, 35)
n 11 (6, 20) 6 (2, 13) 3 (1, 7) 4 (2, 8) 3 (2, 11) 3 (1, 8) 2 (1, 8) 3 (1, 6)
post_p 0.28 (0.09, 0.47) 0.33 (0.16, 0.47) 0.34 (0.19, 0.48) 0.41 (0.26, 0.49) 0.35 (0.19, 0.49) 0.35 (0.13, 0.47) 0.38 (0.19, 0.49) 0.34 (0.14, 0.46)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.146 (0.11, 0.227) 0.143 (0.104, 0.516) 0.207 (0.122, 1.072) 0.155 (0.097, 0.268) 0.151 (0.095, 0.33) 0.198 (0.1, 0.814) 0.168 (0.094, 1.099) 0.247 (0.095, 0.766)
Hormone_therapies count 29 29 29 29 29 29 29 29
time 20 (11, 29) 20 (11, 29) 20 (11, 29) 20 (11, 29) 20 (11, 29) 20 (11, 29) 20 (11, 29) 20 (11, 29)
n 14 (6, 29) 8 (3, 15) 2 (0, 3) 2 (1, 5) 3 (1, 7) 3 (1, 7) 2 (0, 4) 2 (1, 4)
post_p 0.28 (0.09, 0.42) 0.36 (0.12, 0.48) 0.33 (0.18, 0.49) 0.42 (0.28, 0.47) 0.31 (0.22, 0.44) 0.32 (0.18, 0.49) 0.35 (0.15, 0.47) 0.34 (0.21, 0.47)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.146 (0.112, 0.236) 0.157 (0.091, 0.344) 0.239 (0.117, 0.493) 0.17 (0.044, 1.247) 0.227 (0.142, 1.247) 0.196 (0.104, 0.456) 0.416 (0.075, 0.955) 0.228 (0.094, 1.164)
Niraparib count 30 30 30 30 30 30 30 30
time 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33) 19 (12, 33)
n 10 (5, 40) 6 (4, 19) 3 (1, 8) 2 (1, 9) 3 (0, 7) 3 (1, 5) 3 (2, 6) 3 (1, 7)
post_p 0.24 (0.12, 0.49) 0.38 (0.16, 0.46) 0.35 (0.18, 0.47) 0.33 (0.22, 0.48) 0.35 (0.23, 0.46) 0.38 (0.24, 0.48) 0.4 (0.22, 0.49) 0.35 (0.15, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.159 (0.114, 0.416) 0.131 (0.1, 0.333) 0.166 (0.108, 1.105) 0.234 (0.116, 0.635) 0.168 (0.13, 0.55) 0.184 (0.12, 0.664) 0.181 (0.109, 0.324) 0.165 (0.093, 0.544)
Taxel_therapies count 29 29 29 29 29 29 29 29
time 22 (9, 33) 22 (9, 33) 22 (9, 33) 22 (9, 33) 22 (9, 33) 22 (9, 33) 22 (9, 33) 22 (9, 33)
n 11 (5, 27) 10 (5, 16) 2 (0, 5) 2 (0, 4) 4 (1, 11) 4 (2, 8) 2 (0, 5) 2 (1, 5)
post_p 0.34 (0.17, 0.46) 0.25 (0.13, 0.43) 0.31 (0.19, 0.43) 0.4 (0.28, 0.49) 0.38 (0.19, 0.46) 0.35 (0.14, 0.48) 0.33 (0.21, 0.45) 0.36 (0.22, 0.49)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.143 (0.103, 0.246) 0.15 (0.108, 0.197) 0.292 (0.148, 0.545) 0.18 (0.108, 0.793) 0.174 (0.124, 0.523) 0.137 (0.07, 0.462) 0.205 (0.02, 0.733) 0.196 (0.107, 0.78)