Hormone_therapies more effective in the TP53- & AR- biomarker signature
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.042, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 23.4, median = 16.9 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.67, hr = 0.36 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.042, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 23.4, median = 16.9 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.67, hr = 0.36 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.042, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 23.4, median = 16.9 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.67, hr = 0.36 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.042, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 23.4, median = 16.9 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.67, hr = 0.36 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.094, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 10.4, median = 7.5 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1.18, hr = 0.84 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.042, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 23.4, median = 16.9 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 2.67, hr = 0.36 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| DRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.094, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 10.4, median = 7.5 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1.18, hr = 0.84 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.094, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 10.4, median = 7.5 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1.18, hr = 0.84 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 |
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The overall error was 0.132.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.062 0.034 0.016 0.028
The overall power was 0.81.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.81 0.00 0.00 0.00
| signature | var | Carboplatin | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|---|
| all | graduation | 2 | 0 | 35 | 2 | 4 |
| futility | 2 | 0 | 1 | 3 | 3 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 166 (119, 235) | 418 (351, 460) | 158 (95, 262) | 167 (122, 252) | 168 (120, 246) | |
| n_unique | 152 (109, 219) | 386 (324, 426) | 145 (88, 246) | 155 (111, 237) | 155 (111, 230) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | 7 (6, 11) | NA (NA, NA) | 4 (3, 6) | 22 (6, 28) | 6 (4, 6) | |
| post_p | 0.05 (0, 0.29) | NA (NA, NA) | 0.97 (0.64, 1) | 0.05 (0, 0.34) | 0.04 (0, 0.29) | |
| rate | 0.113 (0.102, 0.126) | 0.094 (0.087, 0.102) | 0.078 (0.06, 0.09) | 0.112 (0.101, 0.126) | 0.113 (0.102, 0.128) | |
| DRD+ | graduation | 1 | 0 | 7 | 2 | 0 |
| futility | 41 | 0 | 2 | 42 | 40 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 58 (39, 81) | 112 (92, 128) | 37 (18, 58) | 58 (37, 80) | 47 (26, 70) | |
| n_unique | 53 (35, 74) | 102 (84, 118) | 33 (17, 53) | 53 (33, 73) | 43 (24, 65) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | 24 (15, 34) | NA (NA, NA) | 26 (20, 29) | 24 (14, 34) | 26 (20, 34) | |
| post_p | 0.2 (0.02, 0.67) | NA (NA, NA) | 0.62 (0.18, 0.95) | 0.19 (0.02, 0.68) | 0.26 (0.04, 0.71) | |
| rate | 0.114 (0.094, 0.141) | 0.097 (0.083, 0.113) | 0.091 (0.068, 0.125) | 0.115 (0.096, 0.143) | 0.112 (0.093, 0.146) | |
| TEfus+ | graduation | 2 | 0 | 10 | 3 | 3 |
| futility | 42 | 0 | 3 | 30 | 48 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 68 (42, 97) | 151 (127, 173) | 59 (28, 88) | 69 (45, 98) | 71 (42, 100) | |
| n_unique | 62 (39, 89) | 138 (117, 158) | 55 (26, 80) | 64 (40, 90) | 66 (39, 92) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (35, 36) | |
| time_stop | 20 (15, 35) | NA (NA, NA) | 16 (12, 28) | 21 (14, 34) | 20 (11, 32) | |
| post_p | 0.27 (0.04, 0.73) | NA (NA, NA) | 0.72 (0.24, 0.97) | 0.27 (0.03, 0.68) | 0.24 (0.04, 0.7) | |
| rate | 0.113 (0.096, 0.135) | 0.1 (0.088, 0.113) | 0.092 (0.072, 0.115) | 0.112 (0.096, 0.139) | 0.114 (0.097, 0.139) | |
| TP53- & AR- | graduation | 1 | 0 | 405 | 3 | 1 |
| futility | 391 | 0 | 2 | 382 | 396 | |
| max_n | 16 | 0 | 49 | 27 | 11 | |
| n | 44 (26, 122) | 177 (109, 206) | 34 (25, 150) | 46 (25, 134) | 41 (25, 120) | |
| n_unique | 40 (23, 114) | 165 (98, 193) | 32 (24, 141) | 42 (23, 127) | 36 (23, 111) | |
| time_trial | 23 (14, 36) | 36 (36, 36) | 10 (7, 36) | 24 (14, 36) | 25 (14, 36) | |
| time_stop | 20 (13, 31) | NA (NA, NA) | 9 (6, 20) | 21 (13, 32) | 21 (13, 33) | |
| post_p | 0.01 (0, 0.15) | NA (NA, NA) | 1 (0.97, 1) | 0.02 (0, 0.12) | 0.01 (0, 0.12) | |
| rate | 0.115 (0.095, 0.143) | 0.075 (0.064, 0.084) | 0.041 (0.031, 0.051) | 0.114 (0.097, 0.145) | 0.116 (0.098, 0.152) | |
| TP53+ | graduation | 3 | 0 | 3 | 4 | 9 |
| futility | 35 | 0 | 29 | 30 | 29 | |
| max_n | 8 | 0 | 10 | 9 | 12 | |
| n | 82 (54, 119) | 184 (162, 210) | 84 (33, 122) | 86 (51, 126) | 89 (53, 127) | |
| n_unique | 76 (49, 111) | 170 (148, 194) | 76 (31, 114) | 79 (47, 117) | 81 (49, 118) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | 20 (13, 35) | NA (NA, NA) | 19 (11, 29) | 19 (11, 32) | 15 (8, 31) | |
| post_p | 0.49 (0.1, 0.9) | NA (NA, NA) | 0.52 (0.09, 0.89) | 0.51 (0.1, 0.88) | 0.53 (0.11, 0.9) | |
| rate | 0.113 (0.097, 0.138) | 0.113 (0.101, 0.124) | 0.112 (0.096, 0.137) | 0.113 (0.097, 0.135) | 0.112 (0.097, 0.135) |
| subtype | var | Carboplatin | Control | Hormone_therapies | Niraparib | Taxel_therapies |
|---|---|---|---|---|---|---|
| —- | graduation | 396 | 0 | 439 | 387 | 404 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 16 | 0 | 49 | 27 | 11 | |
| n | 19 (8, 74) | 114 (70, 136) | 27 (19, 107) | 22 (8, 83) | 21 (8, 76) | |
| n_unique | 18 (7, 71) | 106 (62, 128) | 25 (17, 103) | 20 (7, 79) | 19 (7, 72) | |
| post_p | 0.08 (0.01, 0.31) | NA (NA, NA) | 1 (0.93, 1) | 0.07 (0, 0.32) | 0.06 (0.01, 0.3) | |
| rate | 0.117 (0.09, 0.173) | 0.074 (0.064, 0.087) | 0.041 (0.03, 0.053) | 0.116 (0.09, 0.18) | 0.119 (0.093, 0.183) | |
| —+ | graduation | 403 | 0 | 439 | 389 | 409 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 16 | 0 | 49 | 27 | 11 | |
| n | 6 (2, 17) | 20 (12, 28) | 4 (2, 14) | 6 (2, 19) | 7 (3, 17) | |
| n_unique | 5 (1, 16) | 18 (10, 26) | 4 (1, 13) | 6 (2, 17) | 6 (2, 16) | |
| post_p | 0.3 (0.12, 0.61) | NA (NA, NA) | 0.83 (0.45, 0.98) | 0.27 (0.09, 0.57) | 0.24 (0.08, 0.52) | |
| rate | 0.127 (0.075, 0.328) | 0.076 (0.051, 0.11) | 0.044 (0.018, 0.096) | 0.127 (0.077, 0.342) | 0.136 (0.083, 0.299) | |
| –+- | graduation | 41 | 0 | 68 | 36 | 45 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 8 | 0 | 10 | 9 | 12 | |
| n | 22 (7, 52) | 62 (49, 77) | 26 (8, 56) | 24 (6, 54) | 26 (8, 57) | |
| n_unique | 20 (6, 50) | 57 (45, 72) | 24 (7, 52) | 22 (5, 50) | 23 (7, 54) | |
| post_p | 0.43 (0.11, 0.85) | NA (NA, NA) | 0.46 (0.1, 0.87) | 0.42 (0.11, 0.86) | 0.45 (0.12, 0.88) | |
| rate | 0.12 (0.092, 0.206) | 0.112 (0.094, 0.136) | 0.118 (0.09, 0.191) | 0.118 (0.091, 0.211) | 0.117 (0.088, 0.202) | |
| –++ | graduation | 76 | 0 | 79 | 66 | 88 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 8 | 0 | 10 | 9 | 12 | |
| n | 14 (4, 34) | 41 (32, 53) | 17 (4, 36) | 14 (5, 35) | 18 (7, 41) | |
| n_unique | 12 (3, 31) | 38 (29, 50) | 15 (3, 34) | 14 (4, 33) | 17 (6, 39) | |
| post_p | 0.45 (0.15, 0.85) | NA (NA, NA) | 0.49 (0.15, 0.87) | 0.44 (0.14, 0.83) | 0.48 (0.13, 0.87) | |
| rate | 0.119 (0.085, 0.276) | 0.113 (0.09, 0.143) | 0.119 (0.082, 0.227) | 0.121 (0.086, 0.228) | 0.117 (0.089, 0.195) | |
| -+– | graduation | 401 | 0 | 439 | 394 | 407 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 16 | 0 | 49 | 26 | 11 | |
| n | 8 (3, 20) | 19 (11, 27) | 2 (0, 11) | 8 (3, 19) | 7 (2, 17) | |
| n_unique | 7 (3, 18) | 18 (10, 25) | 1 (0, 11) | 7 (2, 18) | 6 (1, 16) | |
| post_p | 0.25 (0.09, 0.58) | NA (NA, NA) | 0.78 (0.42, 0.96) | 0.27 (0.09, 0.58) | 0.3 (0.11, 0.62) | |
| rate | 0.126 (0.079, 0.281) | 0.076 (0.052, 0.11) | 0.043 (0, 0.129) | 0.127 (0.08, 0.301) | 0.126 (0.078, 0.363) | |
| -+-+ | graduation | 407 | 0 | 439 | 395 | 412 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 16 | 0 | 49 | 26 | 11 | |
| n | 8 (3, 19) | 20 (12, 28) | 2 (0, 11) | 8 (3, 20) | 6 (2, 18) | |
| n_unique | 7 (3, 17) | 18 (11, 26) | 2 (0, 11) | 7 (3, 18) | 5 (2, 17) | |
| post_p | 0.26 (0.1, 0.58) | NA (NA, NA) | 0.75 (0.4, 0.96) | 0.25 (0.08, 0.56) | 0.3 (0.11, 0.6) | |
| rate | 0.122 (0.081, 0.259) | 0.074 (0.052, 0.109) | 0.049 (0.015, 0.135) | 0.129 (0.085, 0.302) | 0.125 (0.078, 0.308) | |
| -++- | graduation | 74 | 0 | 77 | 71 | 76 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 8 | 0 | 10 | 9 | 12 | |
| n | 6 (2, 13) | 12 (7, 17) | 4 (1, 11) | 6 (2, 12) | 4 (1, 11) | |
| n_unique | 5 (2, 12) | 11 (7, 16) | 4 (1, 10) | 6 (2, 11) | 4 (1, 10) | |
| post_p | 0.46 (0.2, 0.8) | NA (NA, NA) | 0.47 (0.22, 0.82) | 0.44 (0.21, 0.82) | 0.45 (0.23, 0.81) | |
| rate | 0.135 (0.074, 0.391) | 0.117 (0.073, 0.179) | 0.13 (0.063, 0.45) | 0.131 (0.071, 0.323) | 0.132 (0.066, 0.418) | |
| -+++ | graduation | 102 | 0 | 88 | 97 | 113 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 8 | 0 | 10 | 9 | 12 | |
| n | 6 (2, 13) | 12 (7, 18) | 4 (1, 10) | 6 (2, 13) | 4 (1, 10) | |
| n_unique | 5 (2, 12) | 11 (6, 16) | 4 (1, 9) | 5 (2, 12) | 4 (1, 9) | |
| post_p | 0.44 (0.23, 0.82) | NA (NA, NA) | 0.47 (0.23, 0.82) | 0.44 (0.2, 0.84) | 0.46 (0.22, 0.82) | |
| rate | 0.139 (0.07, 0.322) | 0.118 (0.078, 0.175) | 0.129 (0.065, 0.383) | 0.137 (0.072, 0.396) | 0.132 (0.068, 0.431) | |
| +— | graduation | 4 | 0 | 36 | 5 | 7 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 8 (3, 17) | 20 (14, 27) | 8 (2, 18) | 8 (2, 18) | 10 (4, 20) | |
| n_unique | 7 (3, 16) | 18 (12, 25) | 7 (2, 17) | 7 (2, 16) | 9 (3, 19) | |
| post_p | 0.48 (0.19, 0.85) | NA (NA, NA) | 0.48 (0.2, 0.84) | 0.44 (0.19, 0.85) | 0.45 (0.15, 0.83) | |
| rate | 0.12 (0.075, 0.283) | 0.113 (0.085, 0.169) | 0.125 (0.074, 0.265) | 0.125 (0.075, 0.308) | 0.124 (0.08, 0.305) | |
| +–+ | graduation | 48 | 0 | 49 | 36 | 58 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 6 (2, 15) | 16 (10, 22) | 6 (2, 15) | 6 (2, 15) | 8 (3, 17) | |
| n_unique | 6 (2, 14) | 15 (10, 21) | 6 (1, 14) | 6 (2, 14) | 7 (2, 15) | |
| post_p | 0.47 (0.21, 0.83) | NA (NA, NA) | 0.45 (0.2, 0.82) | 0.46 (0.21, 0.83) | 0.43 (0.17, 0.85) | |
| rate | 0.124 (0.07, 0.343) | 0.114 (0.083, 0.162) | 0.128 (0.075, 0.334) | 0.127 (0.071, 0.392) | 0.13 (0.079, 0.321) | |
| +-+- | graduation | 41 | 0 | 68 | 36 | 45 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 8 | 0 | 10 | 9 | 12 | |
| n | 6 (2, 14) | 16 (11, 23) | 6 (2, 14) | 7 (2, 15) | 8 (3, 16) | |
| n_unique | 5 (2, 13) | 15 (9, 21) | 5 (1, 13) | 6 (2, 14) | 7 (3, 16) | |
| post_p | 0.48 (0.21, 0.84) | NA (NA, NA) | 0.43 (0.2, 0.81) | 0.48 (0.22, 0.84) | 0.45 (0.19, 0.82) | |
| rate | 0.122 (0.071, 0.332) | 0.116 (0.081, 0.17) | 0.133 (0.073, 0.34) | 0.125 (0.07, 0.293) | 0.127 (0.081, 0.281) | |
| +-++ | graduation | 76 | 0 | 79 | 66 | 88 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 8 | 0 | 10 | 9 | 12 | |
| n | 6 (2, 15) | 16 (10, 22) | 6 (1, 15) | 6 (2, 14) | 7 (2, 17) | |
| n_unique | 6 (2, 14) | 14 (10, 20) | 5 (1, 13) | 6 (2, 14) | 7 (2, 16) | |
| post_p | 0.49 (0.21, 0.83) | NA (NA, NA) | 0.44 (0.2, 0.8) | 0.48 (0.2, 0.82) | 0.45 (0.19, 0.81) | |
| rate | 0.122 (0.073, 0.362) | 0.113 (0.081, 0.166) | 0.127 (0.074, 0.392) | 0.122 (0.068, 0.358) | 0.128 (0.081, 0.312) | |
| ++– | graduation | 45 | 0 | 45 | 47 | 47 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 6 (2, 13) | 11 (7, 16) | 4 (1, 10) | 6 (2, 12) | 4 (1, 10) | |
| n_unique | 6 (2, 12) | 10 (6, 15) | 4 (1, 9) | 5 (2, 11) | 4 (1, 10) | |
| post_p | 0.49 (0.21, 0.83) | NA (NA, NA) | 0.46 (0.23, 0.8) | 0.45 (0.19, 0.83) | 0.46 (0.22, 0.78) | |
| rate | 0.123 (0.069, 0.339) | 0.116 (0.074, 0.181) | 0.13 (0.067, 0.381) | 0.133 (0.073, 0.383) | 0.129 (0.068, 0.39) | |
| ++-+ | graduation | 77 | 0 | 58 | 73 | 91 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 6 (2, 13) | 11 (7, 17) | 4 (1, 10) | 6 (2, 13) | 4 (1, 11) | |
| n_unique | 5 (2, 12) | 10 (6, 16) | 3 (1, 9) | 6 (2, 13) | 4 (1, 10) | |
| post_p | 0.47 (0.2, 0.82) | NA (NA, NA) | 0.46 (0.22, 0.8) | 0.47 (0.21, 0.85) | 0.46 (0.23, 0.82) | |
| rate | 0.128 (0.074, 0.373) | 0.116 (0.075, 0.177) | 0.132 (0.07, 0.493) | 0.125 (0.07, 0.392) | 0.132 (0.07, 0.428) | |
| +++- | graduation | 74 | 0 | 77 | 71 | 76 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 8 | 0 | 10 | 9 | 12 | |
| n | 6 (2, 12) | 11 (7, 17) | 4 (1, 10) | 6 (2, 13) | 4 (1, 11) | |
| n_unique | 5 (2, 12) | 10 (6, 16) | 4 (1, 9) | 5 (2, 12) | 4 (1, 10) | |
| post_p | 0.45 (0.2, 0.83) | NA (NA, NA) | 0.48 (0.21, 0.82) | 0.44 (0.2, 0.81) | 0.46 (0.24, 0.83) | |
| rate | 0.126 (0.07, 0.333) | 0.111 (0.074, 0.176) | 0.124 (0.065, 0.421) | 0.131 (0.074, 0.388) | 0.127 (0.063, 0.503) | |
| ++++ | graduation | 102 | 0 | 88 | 97 | 113 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 8 | 0 | 10 | 9 | 12 | |
| n | 6 (2, 13) | 12 (7, 17) | 4 (1, 11) | 6 (2, 12) | 4 (1, 11) | |
| n_unique | 5 (2, 12) | 11 (7, 16) | 4 (1, 10) | 5 (2, 11) | 4 (1, 10) | |
| post_p | 0.43 (0.19, 0.85) | NA (NA, NA) | 0.44 (0.23, 0.81) | 0.46 (0.2, 0.81) | 0.47 (0.23, 0.81) | |
| rate | 0.132 (0.07, 0.359) | 0.115 (0.073, 0.175) | 0.131 (0.065, 0.438) | 0.125 (0.071, 0.382) | 0.127 (0.062, 0.422) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 35 | 4 | 2 | 2 |
| time_stop | 4 (3, 7) | 6 (5, 7) | 6 (6, 7) | 6 (5, 8) | |
| n_trt | 29 (26, 49) | 38 (28, 43) | 28 (26, 30) | 31 (28, 34) | |
| n_control | 49 (40, 71) | 70 (52, 78) | 76 (68, 84) | 67 (56, 78) | |
| post_p | 0.94 (0.88, 0.98) | 0.92 (0.9, 0.95) | 0.98 (0.98, 0.98) | 0.91 (0.88, 0.95) | |
| order | 1 (1, 1) | 1 (1, 1) | 1.5 (1.1, 1.9) | 1 (1, 1) | |
| TP53- & AR- | count | 405 | 1 | 1 | 3 |
| time_stop | 9 (6, 21) | 11 (11, 11) | 8 (8, 8) | 13 (10, 15) | |
| n_trt | 33 (26, 79) | 27 (27, 27) | 25 (25, 25) | 26 (25, 48) | |
| n_control | 41 (28, 104) | 37 (37, 37) | 37 (37, 37) | 58 (39, 79) | |
| post_p | 0.95 (0.87, 1) | 0.96 (0.96, 0.96) | 0.85 (0.85, 0.85) | 0.9 (0.88, 0.95) | |
| order | 1 (1, 1) | 1 (1, 1) | 2 (2, 2) | 2 (1.2, 2) | |
| TP53+ | count | 3 | 9 | 3 | 4 |
| time_stop | 12 (10, 14) | 9 (7, 13) | 11 (9, 13) | 16 (10, 20) | |
| n_trt | 42 (30, 46) | 29 (26, 40) | 33 (28, 40) | 40 (29, 52) | |
| n_control | 44 (35, 70) | 42 (31, 71) | 57 (43, 59) | 70 (47, 90) | |
| post_p | 0.94 (0.94, 0.97) | 0.96 (0.91, 0.98) | 0.97 (0.89, 0.99) | 0.98 (0.94, 1) | |
| order | 2 (1.2, 2) | 1 (1, 2.2) | 2 (1.2, 2) | 1.5 (1, 2) | |
| DRD+ | count | 7 | 1 | 2 | |
| time_stop | 26 (20, 30) | 10 (10, 10) | 12 (9, 14) | ||
| n_trt | 26 (25, 34) | 25 (25, 25) | 31 (27, 35) | ||
| n_control | 80 (55, 86) | 29 (29, 29) | 36 (30, 42) | ||
| post_p | 0.95 (0.93, 0.99) | 0.92 (0.92, 0.92) | 0.9 (0.88, 0.91) | ||
| order | 2 (2, 2.4) | 2 (2, 2) | 1 (1, 1) | ||
| TEfus+ | count | 10 | 3 | 2 | 3 |
| time_stop | 15 (12, 23) | 11 (8, 13) | 12 (10, 14) | 12 (11, 13) | |
| n_trt | 28 (25, 36) | 25 (25, 35) | 28 (27, 29) | 29 (28, 29) | |
| n_control | 56 (43, 85) | 46 (30, 54) | 58 (47, 70) | 45 (39, 50) | |
| post_p | 0.98 (0.93, 1) | 0.94 (0.89, 0.94) | 0.96 (0.96, 0.96) | 0.92 (0.9, 0.92) | |
| order | 2 (2, 2.1) | 2 (1.2, 2) | 2.5 (2.1, 2.9) | 2 (2, 2) |
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 1 | 3 | 2 | 3 |
| time_stop | 3 (3, 3) | 5 (3, 6) | 10 (8, 12) | 28 (23, 28) | |
| n_trt | 26 (26, 26) | 28 (26, 38) | 44 (29, 58) | 107 (85, 167) | |
| n_control | 31 (31, 31) | 56 (38, 63) | 105 (84, 126) | 332 (268, 347) | |
| post_p | 0.15 (0.15, 0.15) | 0.08 (0.06, 0.17) | 0.02 (0.01, 0.04) | 0 (0, 0.01) | |
| order | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 4 (2.4, 6.4) | |
| TP53- & AR- | count | 2 | 396 | 391 | 382 |
| time_stop | 6 (6, 7) | 21 (13, 33) | 20 (13, 31) | 21 (13, 32) | |
| n_trt | 28 (26, 29) | 36 (25, 94) | 38 (26, 87) | 35 (25, 96) | |
| n_control | 33 (32, 34) | 107 (57, 178) | 101 (59, 165) | 104 (58, 174) | |
| post_p | 0.15 (0.13, 0.18) | 0.05 (0, 0.2) | 0.06 (0, 0.2) | 0.05 (0, 0.18) | |
| order | 1 (1, 1) | 2 (1, 4) | 2 (1, 3) | 2 (1, 4) | |
| TP53+ | count | 29 | 29 | 35 | 30 |
| time_stop | 20 (11, 29) | 22 (9, 33) | 20 (13, 35) | 19 (12, 33) | |
| n_trt | 34 (27, 62) | 37 (26, 76) | 38 (26, 61) | 36 (26, 67) | |
| n_control | 95 (40, 148) | 107 (44, 164) | 101 (60, 181) | 94 (53, 170) | |
| post_p | 0.04 (0, 0.19) | 0.06 (0, 0.16) | 0.05 (0.01, 0.14) | 0.05 (0.01, 0.15) | |
| order | 2 (1, 4) | 2 (1, 5) | 2 (1, 5) | 3 (1, 5) | |
| DRD+ | count | 2 | 40 | 41 | 42 |
| time_stop | 26 (24, 27) | 26 (20, 34) | 24 (16, 34) | 26 (14, 34) | |
| n_trt | 26 (25, 27) | 29 (25, 44) | 39 (27, 54) | 36 (26, 52) | |
| n_control | 82 (78, 86) | 78 (55, 114) | 70 (45, 105) | 78 (42, 106) | |
| post_p | 0.04 (0.02, 0.07) | 0.04 (0, 0.17) | 0.04 (0.01, 0.14) | 0.04 (0.01, 0.1) | |
| order | 3.5 (2.3, 4.7) | 4 (1, 5) | 3 (2, 5) | 3 (1, 5) | |
| TEfus+ | count | 3 | 48 | 42 | 30 |
| time_stop | 26 (19, 28) | 20 (12, 32) | 20 (15, 35) | 22 (16, 34) | |
| n_trt | 29 (27, 36) | 38 (26, 63) | 36 (26, 58) | 42 (28, 60) | |
| n_control | 121 (72, 126) | 81 (41, 138) | 90 (56, 148) | 88 (54, 140) | |
| post_p | 0.12 (0.05, 0.14) | 0.04 (0.01, 0.15) | 0.05 (0.01, 0.12) | 0.05 (0.01, 0.19) | |
| order | 3 (1.4, 3.8) | 2.5 (1, 4.3) | 3 (1, 5) | 3 (1, 6.1) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Carboplatin | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| time | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | ||
| n | 4 (3, 4) | 1 (1, 1) | 3 (1, 5) | 0 (0, 0) | 4 (4, 4) | 0 (0, 1) | 2 (2, 3) | 2 (2, 2) | 0 (0, 1) | 2 (1, 4) | 2 (2, 3) | 1 (1, 1) | 2 (2, 2) | 1 (0, 2) | 1 (0, 2) | 2 (1, 2) | ||
| post_p | 0.59 (0.57, 0.6) | 0.56 (0.56, 0.56) | 0.59 (0.54, 0.64) | NA (NA, NA) | 0.72 (0.71, 0.73) | 0.57 (0.57, 0.57) | 0.52 (0.52, 0.52) | 0.56 (0.53, 0.58) | 0.5 (0.5, 0.5) | 0.53 (0.52, 0.53) | 0.63 (0.58, 0.68) | 0.51 (0.5, 0.52) | 0.77 (0.76, 0.78) | 0.51 (0.51, 0.51) | 0.76 (0.76, 0.76) | 0.63 (0.58, 0.68) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0 (0, 0) | 0 (0, 0) | 0.037 (0.007, 0.066) | NA (NA, NA) | 0.031 (0.006, 0.056) | 0 (0, 0) | 0.043 (0.009, 0.078) | 0.152 (0.03, 0.273) | 0 (0, 0) | 0.074 (0.015, 0.133) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| Hormone_therapies | count | 35 | 35 | 35 | 35 | 35 | 35 | 35 | 35 | 35 | 35 | 35 | 35 | 35 | 35 | 35 | 35 | |
| time | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | 4 (3, 7) | ||
| n | 15 (12, 22) | 2 (1, 6) | 6 (3, 10) | 2 (0, 7) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 1 (0, 2) | 1 (0, 3) | 0 (0, 2) | 0 (0, 2) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | 0 (0, 1) | ||
| post_p | 0.76 (0.64, 0.9) | 0.63 (0.54, 0.71) | 0.65 (0.54, 0.77) | 0.59 (0.52, 0.73) | 0.54 (0.51, 0.58) | 0.54 (0.53, 0.57) | 0.54 (0.51, 0.56) | 0.51 (0.51, 0.61) | 0.6 (0.53, 0.69) | 0.57 (0.51, 0.69) | 0.58 (0.51, 0.64) | 0.59 (0.52, 0.67) | NA (NA, NA) | 0.52 (0.51, 0.52) | 0.52 (0.51, 0.55) | 0.52 (0.51, 0.54) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.023 (0, 0.048) | 0 (0, 0.025) | 0.05 (0, 0.134) | 0 (0, 0.083) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.094) | 0 (0, 0.108) | 0 (0, 0.54) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.205) | 0 (0, 0) | ||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |
| time | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | 6 (5, 8) | ||
| n | 2 (1, 3) | 0 (0, 1) | 6 (4, 8) | 1 (1, 1) | 2 (1, 3) | 2 (2, 3) | 3 (3, 3) | 2 (2, 2) | 2 (1, 3) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 2 (1, 3) | 3 (2, 4) | 2 (1, 2) | 2 (2, 3) | ||
| post_p | 0.58 (0.55, 0.6) | 0.56 (0.56, 0.56) | 0.51 (0.51, 0.52) | 0.54 (0.52, 0.56) | 0.62 (0.57, 0.67) | 0.63 (0.59, 0.66) | 0.73 (0.71, 0.75) | 0.6 (0.56, 0.64) | 0.56 (0.54, 0.59) | NA (NA, NA) | 0.51 (0.51, 0.51) | 0.51 (0.51, 0.51) | 0.63 (0.59, 0.66) | 0.62 (0.62, 0.62) | 0.57 (0.54, 0.59) | 0.65 (0.6, 0.71) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0 (0, 0) | 0 (0, 0) | 0.096 (0.083, 0.108) | 0 (0, 0) | 0 (0, 0) | 0.057 (0.011, 0.102) | 0.061 (0.012, 0.111) | 0.065 (0.013, 0.117) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.096 (0.019, 0.173) | 0.078 (0.016, 0.14) | 0.024 (0.005, 0.043) | ||
| Taxel_therapies | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
| time | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | 6 (5, 7) | ||
| n | 4 (2, 8) | 2 (0, 4) | 6 (3, 9) | 6 (4, 7) | 0 (0, 2) | 0 (0, 2) | 0 (0, 1) | 0 (0, 1) | 6 (4, 6) | 3 (2, 3) | 3 (2, 4) | 4 (2, 5) | 0 (0, 1) | 0 (0, 1) | 0 (0, 0) | 0 (0, 1) | ||
| post_p | 0.56 (0.54, 0.65) | 0.59 (0.52, 0.66) | 0.74 (0.66, 0.89) | 0.66 (0.56, 0.72) | 0.54 (0.52, 0.55) | 0.57 (0.55, 0.58) | 0.59 (0.59, 0.59) | 0.51 (0.51, 0.51) | 0.63 (0.54, 0.66) | 0.64 (0.53, 0.75) | 0.73 (0.61, 0.81) | 0.59 (0.52, 0.73) | 0.56 (0.56, 0.56) | 0.51 (0.51, 0.51) | NA (NA, NA) | 0.52 (0.52, 0.52) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.023 (0, 0.088) | 0 (0, 0) | 0 (0, 0.03) | 0.019 (0, 0.067) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.096 (0.056, 0.172) | 0.108 (0.032, 0.138) | 0 (0, 0.033) | 0.041 (0, 0.113) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | ||
| DRD+ | Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | ||||||||||
| n | 9 (9, 9) | 4 (4, 4) | 2 (2, 2) | 1 (1, 1) | 5 (5, 5) | 3 (3, 3) | 0 (0, 0) | 1 (1, 1) | ||||||||||
| post_p | 0.82 (0.82, 0.82) | 0.71 (0.71, 0.71) | 0.58 (0.58, 0.58) | 0.51 (0.51, 0.51) | 0.88 (0.88, 0.88) | 0.7 (0.7, 0.7) | NA (NA, NA) | 0.55 (0.55, 0.55) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.08 (0.08, 0.08) | 0.049 (0.049, 0.049) | 0 (0, 0) | 0 (0, 0) | 0.085 (0.085, 0.085) | 0.057 (0.057, 0.057) | NA (NA, NA) | 0 (0, 0) | ||||||||||
| Hormone_therapies | count | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | |||||||||
| time | 26 (20, 30) | 26 (20, 30) | 26 (20, 30) | 26 (20, 30) | 26 (20, 30) | 26 (20, 30) | 26 (20, 30) | 26 (20, 30) | ||||||||||
| n | 1 (0, 4) | 1 (1, 8) | 4 (3, 8) | 3 (3, 7) | 2 (2, 3) | 3 (1, 4) | 4 (1, 5) | 4 (3, 9) | ||||||||||
| post_p | 0.74 (0.64, 0.76) | 0.84 (0.64, 0.91) | 0.72 (0.62, 0.87) | 0.73 (0.64, 0.84) | 0.6 (0.52, 0.74) | 0.65 (0.52, 0.76) | 0.71 (0.6, 0.84) | 0.71 (0.52, 0.82) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.03 (0.007, 0.052) | 0 (0, 0.057) | 0.063 (0.036, 0.116) | 0.057 (0.019, 0.097) | 0.055 (0, 0.083) | 0.09 (0.016, 0.164) | 0.065 (0.047, 0.087) | 0.065 (0.028, 0.108) | ||||||||||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 12 (9, 14) | 12 (9, 14) | 12 (9, 14) | 12 (9, 14) | 12 (9, 14) | 12 (9, 14) | 12 (9, 14) | 12 (9, 14) | ||||||||||
| n | 4 (3, 4) | 7 (5, 9) | 5 (4, 6) | 2 (2, 3) | 5 (5, 5) | 0 (0, 1) | 4 (4, 4) | 4 (3, 4) | ||||||||||
| post_p | 0.6 (0.6, 0.62) | 0.72 (0.7, 0.74) | 0.84 (0.76, 0.92) | 0.55 (0.51, 0.59) | 0.68 (0.63, 0.73) | 0.52 (0.52, 0.52) | 0.52 (0.52, 0.52) | 0.59 (0.52, 0.66) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.042 (0.008, 0.076) | 0.077 (0.07, 0.083) | 0.012 (0.002, 0.021) | 0.082 (0.016, 0.147) | 0.04 (0.008, 0.072) | 0.112 (0.112, 0.112) | 0.098 (0.075, 0.121) | 0.157 (0.07, 0.244) | ||||||||||
| TEfus+ | Carboplatin | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||
| time | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | ||||||||||
| n | 2 (1, 2) | 4 (2, 5) | 3 (3, 3) | 4 (3, 5) | 4 (3, 6) | 2 (1, 4) | 6 (3, 8) | 4 (3, 4) | ||||||||||
| post_p | 0.58 (0.52, 0.64) | 0.58 (0.56, 0.59) | 0.6 (0.53, 0.66) | 0.72 (0.67, 0.77) | 0.76 (0.74, 0.79) | 0.69 (0.66, 0.72) | 0.81 (0.81, 0.81) | 0.65 (0.65, 0.66) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0) | 0.114 (0.113, 0.115) | 0.085 (0.069, 0.102) | 0.018 (0.004, 0.032) | 0.026 (0.005, 0.048) | 0.022 (0.004, 0.039) | 0.13 (0.127, 0.134) | 0.048 (0.041, 0.054) | ||||||||||
| Hormone_therapies | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | |||||||||
| time | 15 (12, 23) | 15 (12, 23) | 15 (12, 23) | 15 (12, 23) | 15 (12, 23) | 15 (12, 23) | 15 (12, 23) | 15 (12, 23) | ||||||||||
| n | 5 (3, 6) | 6 (5, 14) | 2 (1, 4) | 2 (1, 4) | 2 (1, 7) | 5 (2, 8) | 2 (0, 4) | 1 (0, 4) | ||||||||||
| post_p | 0.82 (0.72, 0.9) | 0.74 (0.57, 0.88) | 0.73 (0.6, 0.9) | 0.64 (0.5, 0.87) | 0.65 (0.55, 0.78) | 0.64 (0.53, 0.76) | 0.57 (0.52, 0.72) | 0.61 (0.56, 0.75) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.023 (0, 0.057) | 0.073 (0.051, 0.109) | 0 (0, 0.045) | 0 (0, 0.075) | 0.082 (0, 0.107) | 0.076 (0, 0.114) | 0.072 (0, 0.11) | 0 (0, 0.074) | ||||||||||
| Niraparib | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | 12 (11, 13) | ||||||||||
| n | 1 (0, 3) | 8 (6, 9) | 4 (4, 7) | 3 (1, 5) | 2 (1, 3) | 2 (1, 4) | 3 (2, 5) | 4 (4, 4) | ||||||||||
| post_p | 0.52 (0.52, 0.53) | 0.73 (0.59, 0.86) | 0.62 (0.56, 0.79) | 0.56 (0.51, 0.62) | 0.64 (0.54, 0.66) | 0.62 (0.58, 0.65) | 0.67 (0.55, 0.67) | 0.74 (0.71, 0.77) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0) | 0.054 (0.034, 0.072) | 0.048 (0.047, 0.056) | 0.06 (0.012, 0.125) | 0 (0, 0) | 0 (0, 0.037) | 0.101 (0.073, 0.285) | 0.08 (0.016, 0.131) | ||||||||||
| Taxel_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 11 (8, 13) | 11 (8, 13) | 11 (8, 13) | 11 (8, 13) | 11 (8, 13) | 11 (8, 13) | 11 (8, 13) | 11 (8, 13) | ||||||||||
| n | 2 (0, 3) | 15 (12, 17) | 1 (0, 4) | 1 (0, 2) | 3 (2, 5) | 4 (2, 10) | 0 (0, 0) | 0 (0, 2) | ||||||||||
| post_p | 0.54 (0.51, 0.56) | 0.71 (0.7, 0.83) | 0.63 (0.56, 0.7) | 0.59 (0.52, 0.66) | 0.71 (0.63, 0.71) | 0.88 (0.75, 0.93) | NA (NA, NA) | 0.6 (0.6, 0.6) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.045 (0.009, 0.08) | 0.063 (0.062, 0.072) | 0 (0, 0) | 0.032 (0.006, 0.058) | 0.055 (0.011, 0.08) | 0.068 (0.014, 0.076) | NA (NA, NA) | 0 (0, 0) | ||||||||||
| TP53- & AR- | Carboplatin | count | 1 | 1 | 1 | 1 | ||||||||||||
| time | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | ||||||||||||||
| n | 10 (10, 10) | 4 (4, 4) | 7 (7, 7) | 4 (4, 4) | ||||||||||||||
| post_p | 0.73 (0.73, 0.73) | 0.58 (0.58, 0.58) | 0.77 (0.77, 0.77) | 0.55 (0.55, 0.55) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.048 (0.048, 0.048) | 0 (0, 0) | 0.033 (0.033, 0.033) | 0.247 (0.247, 0.247) | ||||||||||||||
| Hormone_therapies | count | 405 | 405 | 405 | 405 | |||||||||||||
| time | 9 (6, 21) | 9 (6, 21) | 9 (6, 21) | 9 (6, 21) | ||||||||||||||
| n | 26 (20, 58) | 4 (2, 11) | 1 (0, 7) | 2 (0, 6) | ||||||||||||||
| post_p | 0.89 (0.75, 1) | 0.71 (0.53, 0.85) | 0.59 (0.51, 0.85) | 0.6 (0.52, 0.79) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.038 (0.015, 0.055) | 0.023 (0, 0.075) | 0 (0, 0.059) | 0 (0, 0.07) | ||||||||||||||
| Niraparib | count | 3 | 3 | 3 | 3 | |||||||||||||
| time | 13 (10, 15) | 13 (10, 15) | 13 (10, 15) | 13 (10, 15) | ||||||||||||||
| n | 14 (13, 24) | 4 (2, 6) | 9 (5, 10) | 4 (2, 9) | ||||||||||||||
| post_p | 0.78 (0.75, 0.84) | 0.56 (0.53, 0.85) | 0.78 (0.62, 0.9) | 0.58 (0.55, 0.7) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.043 (0.009, 0.051) | 0.041 (0.008, 0.042) | 0.044 (0.037, 0.05) | 0.043 (0.009, 0.058) | ||||||||||||||
| Taxel_therapies | count | 1 | 1 | 1 | 1 | |||||||||||||
| time | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | ||||||||||||||
| n | 16 (16, 16) | 4 (4, 4) | 3 (3, 3) | 4 (4, 4) | ||||||||||||||
| post_p | 0.76 (0.76, 0.76) | 0.79 (0.79, 0.79) | 0.72 (0.72, 0.72) | 0.64 (0.64, 0.64) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.078 (0.078, 0.078) | 0 (0, 0) | 0 (0, 0) | 0.056 (0.056, 0.056) | ||||||||||||||
| TP53+ | Carboplatin | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||
| time | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | 11 (9, 13) | ||||||||||
| n | 14 (13, 15) | 5 (2, 9) | 2 (0, 3) | 3 (2, 4) | 2 (2, 4) | 1 (1, 3) | 2 (0, 4) | 4 (3, 4) | ||||||||||
| post_p | 0.81 (0.77, 0.89) | 0.53 (0.53, 0.8) | 0.63 (0.6, 0.65) | 0.66 (0.57, 0.7) | 0.58 (0.58, 0.62) | 0.64 (0.53, 0.64) | 0.59 (0.56, 0.63) | 0.69 (0.63, 0.73) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.043 (0.04, 0.052) | 0.091 (0.018, 0.095) | 0.222 (0.112, 0.332) | 0 (0, 0.09) | 0.091 (0.018, 0.132) | 0 (0, 0.06) | 0.088 (0.068, 0.108) | 0.104 (0.07, 0.153) | ||||||||||
| Hormone_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | 12 (10, 14) | ||||||||||
| n | 18 (13, 23) | 5 (5, 8) | 2 (0, 3) | 2 (1, 3) | 5 (4, 7) | 5 (1, 5) | 2 (0, 4) | 0 (0, 0) | ||||||||||
| post_p | 0.88 (0.81, 0.9) | 0.72 (0.61, 0.81) | 0.61 (0.57, 0.65) | 0.63 (0.63, 0.67) | 0.75 (0.57, 0.81) | 0.54 (0.54, 0.54) | 0.62 (0.56, 0.67) | NA (NA, NA) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.056 (0.052, 0.078) | 0.084 (0.064, 0.085) | 0.067 (0.013, 0.121) | 0 (0, 0.06) | 0.1 (0.046, 0.139) | 0.065 (0.013, 0.116) | 0.027 (0.005, 0.049) | NA (NA, NA) | ||||||||||
| Niraparib | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |||||||||
| time | 16 (10, 20) | 16 (10, 20) | 16 (10, 20) | 16 (10, 20) | 16 (10, 20) | 16 (10, 20) | 16 (10, 20) | 16 (10, 20) | ||||||||||
| n | 16 (11, 22) | 4 (1, 7) | 3 (2, 5) | 4 (1, 10) | 2 (0, 3) | 4 (2, 5) | 3 (2, 4) | 3 (1, 4) | ||||||||||
| post_p | 0.9 (0.8, 0.94) | 0.72 (0.58, 0.77) | 0.72 (0.55, 0.79) | 0.75 (0.56, 0.92) | 0.67 (0.64, 0.7) | 0.75 (0.61, 0.79) | 0.7 (0.59, 0.82) | 0.7 (0.56, 0.86) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.053 (0.035, 0.067) | 0.086 (0.063, 0.111) | 0.107 (0.076, 0.135) | 0.081 (0.018, 0.109) | 0.046 (0.009, 0.082) | 0.065 (0.014, 0.089) | 0.092 (0.022, 0.113) | 0.088 (0.018, 0.122) | ||||||||||
| Taxel_therapies | count | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | |||||||||
| time | 9 (7, 13) | 9 (7, 13) | 9 (7, 13) | 9 (7, 13) | 9 (7, 13) | 9 (7, 13) | 9 (7, 13) | 9 (7, 13) | ||||||||||
| n | 9 (6, 13) | 11 (7, 15) | 0 (0, 2) | 1 (0, 3) | 3 (2, 5) | 3 (2, 5) | 1 (0, 3) | 1 (0, 3) | ||||||||||
| post_p | 0.76 (0.69, 0.86) | 0.81 (0.67, 0.88) | 0.65 (0.56, 0.75) | 0.57 (0.52, 0.63) | 0.57 (0.53, 0.85) | 0.55 (0.51, 0.7) | 0.59 (0.51, 0.72) | 0.62 (0.53, 0.63) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.078 (0.054, 0.116) | 0.05 (0.03, 0.093) | 0 (0, 0) | 0 (0, 0.039) | 0.081 (0, 0.142) | 0.062 (0, 0.092) | 0 (0, 0.078) | 0 (0, 0.034) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Carboplatin | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| time | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | ||
| n | 6 (4, 8) | 0 (0, 0) | 6 (4, 8) | 4 (3, 6) | 5 (5, 5) | 6 (5, 6) | 1 (0, 2) | 1 (0, 2) | 2 (1, 3) | 2 (1, 2) | 2 (1, 3) | 0 (0, 0) | 2 (1, 2) | 2 (0, 3) | 2 (1, 4) | 4 (1, 6) | ||
| post_p | 0.29 (0.2, 0.38) | NA (NA, NA) | 0.34 (0.27, 0.41) | 0.4 (0.37, 0.42) | 0.22 (0.12, 0.33) | 0.45 (0.41, 0.48) | 0.46 (0.46, 0.46) | 0.49 (0.49, 0.49) | 0.45 (0.43, 0.48) | 0.39 (0.31, 0.47) | 0.35 (0.24, 0.46) | NA (NA, NA) | 0.34 (0.31, 0.37) | 0.12 (0.12, 0.12) | 0.33 (0.27, 0.39) | 0.46 (0.46, 0.46) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.161 (0.153, 0.169) | NA (NA, NA) | 0.227 (0.154, 0.299) | 0.203 (0.154, 0.253) | 0.189 (0.09, 0.288) | 0.112 (0.09, 0.135) | 0.08 (0.08, 0.08) | 0.095 (0.095, 0.095) | 0.089 (0.018, 0.161) | 0.171 (0.034, 0.307) | 0.25 (0.218, 0.282) | NA (NA, NA) | 0.209 (0.206, 0.212) | 0.551 (0.551, 0.551) | 0.245 (0.131, 0.359) | 0.041 (0.041, 0.041) | ||
| Hormone_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | 3 (3, 3) | ||
| n | 13 (13, 13) | 2 (2, 2) | 6 (6, 6) | 3 (3, 3) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| post_p | 0.2 (0.2, 0.2) | 0.34 (0.34, 0.34) | 0.36 (0.36, 0.36) | 0.24 (0.24, 0.24) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.102 (0.102, 0.102) | 0.292 (0.292, 0.292) | 0.078 (0.078, 0.078) | 0.206 (0.206, 0.206) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| Niraparib | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
| time | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | 28 (23, 28) | ||
| n | 22 (13, 70) | 5 (2, 15) | 10 (8, 33) | 4 (2, 17) | 10 (4, 18) | 2 (1, 8) | 3 (3, 7) | 1 (1, 2) | 2 (1, 4) | 4 (1, 6) | 3 (2, 7) | 4 (2, 5) | 2 (2, 4) | 3 (3, 5) | 2 (2, 4) | 2 (2, 6) | ||
| post_p | 0.06 (0.05, 0.37) | 0.39 (0.38, 0.39) | 0.14 (0.11, 0.43) | 0.44 (0.21, 0.47) | 0.33 (0.17, 0.4) | 0.32 (0.32, 0.34) | 0.24 (0.19, 0.34) | 0.37 (0.32, 0.38) | 0.41 (0.28, 0.42) | 0.36 (0.35, 0.37) | 0.3 (0.27, 0.45) | 0.35 (0.27, 0.46) | 0.19 (0.18, 0.2) | 0.28 (0.24, 0.3) | 0.18 (0.14, 0.43) | 0.34 (0.24, 0.42) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.106 (0.103, 0.185) | 0.153 (0.113, 2.178) | 0.23 (0.138, 0.234) | 0.122 (0.106, 1.745) | 0.142 (0.105, 0.184) | 0.2 (0.111, 4.306) | 0.296 (0.172, 0.441) | 0.326 (0.234, 0.335) | 0.287 (0.183, 0.304) | 0.144 (0.14, 0.148) | 0.148 (0.122, 0.389) | 0.178 (0.155, 0.39) | 0.418 (0.226, 0.877) | 0.197 (0.121, 0.394) | 0.218 (0.139, 0.299) | 0.267 (0.181, 0.485) | ||
| Taxel_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
| time | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | 5 (3, 6) | ||
| n | 6 (5, 8) | 3 (3, 4) | 3 (2, 10) | 6 (5, 8) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 1) | 3 (3, 4) | 1 (0, 1) | 1 (0, 4) | 4 (1, 4) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| post_p | 0.44 (0.28, 0.46) | 0.45 (0.45, 0.49) | 0.48 (0.16, 0.48) | 0.37 (0.33, 0.47) | 0.24 (0.24, 0.24) | NA (NA, NA) | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.46 (0.46, 0.48) | 0.39 (0.31, 0.47) | 0.43 (0.43, 0.43) | 0.35 (0.28, 0.41) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.114 (0.083, 0.306) | 0.185 (0.037, 0.192) | 0.141 (0.028, 0.234) | 0.128 (0.127, 0.131) | 1.07 (1.07, 1.07) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0.124 (0.025, 0.211) | 0.143 (0.029, 0.258) | 0.712 (0.187, 1.236) | 0.251 (0.216, 0.285) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||
| DRD+ | Carboplatin | count | 41 | 41 | 41 | 41 | 41 | 41 | 41 | 41 | ||||||||
| time | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | ||||||||||
| n | 7 (2, 14) | 7 (3, 14) | 3 (2, 7) | 3 (1, 6) | 4 (1, 8) | 3 (1, 8) | 5 (2, 8) | 4 (1, 7) | ||||||||||
| post_p | 0.38 (0.14, 0.46) | 0.3 (0.12, 0.43) | 0.33 (0.18, 0.46) | 0.37 (0.22, 0.45) | 0.35 (0.23, 0.47) | 0.38 (0.19, 0.47) | 0.38 (0.13, 0.48) | 0.36 (0.15, 0.46) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.129 (0.087, 0.328) | 0.13 (0.089, 0.243) | 0.2 (0.104, 1.192) | 0.203 (0.104, 0.4) | 0.161 (0.107, 0.608) | 0.149 (0.102, 0.597) | 0.154 (0.101, 0.278) | 0.195 (0.091, 0.593) | ||||||||||
| Hormone_therapies | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 26 (24, 27) | 26 (24, 27) | 26 (24, 27) | 26 (24, 27) | 26 (24, 27) | 26 (24, 27) | 26 (24, 27) | 26 (24, 27) | ||||||||||
| n | 0 (0, 1) | 2 (2, 2) | 4 (3, 4) | 7 (6, 8) | 3 (2, 4) | 1 (1, 1) | 2 (1, 4) | 6 (5, 8) | ||||||||||
| post_p | 0.42 (0.42, 0.42) | 0.43 (0.41, 0.44) | 0.24 (0.2, 0.28) | 0.28 (0.22, 0.35) | 0.27 (0.27, 0.28) | 0.43 (0.38, 0.48) | 0.27 (0.22, 0.32) | 0.42 (0.35, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.123 (0.123, 0.123) | 0.11 (0.108, 0.112) | 0.241 (0.21, 0.272) | 0.116 (0.105, 0.128) | 0.362 (0.305, 0.419) | 0.423 (0.246, 0.6) | 5.716 (1.253, 10.18) | 0.124 (0.079, 0.17) | ||||||||||
| Niraparib | count | 42 | 42 | 42 | 42 | 42 | 42 | 42 | 42 | |||||||||
| time | 26 (14, 34) | 26 (14, 34) | 26 (14, 34) | 26 (14, 34) | 26 (14, 34) | 26 (14, 34) | 26 (14, 34) | 26 (14, 34) | ||||||||||
| n | 5 (2, 14) | 6 (3, 18) | 4 (1, 9) | 3 (1, 7) | 4 (1, 6) | 4 (1, 8) | 4 (2, 6) | 4 (2, 8) | ||||||||||
| post_p | 0.29 (0.13, 0.42) | 0.29 (0.13, 0.47) | 0.38 (0.19, 0.46) | 0.32 (0.18, 0.48) | 0.33 (0.21, 0.44) | 0.34 (0.2, 0.46) | 0.36 (0.18, 0.48) | 0.38 (0.2, 0.48) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.128 (0.088, 0.491) | 0.134 (0.088, 0.374) | 0.2 (0.117, 0.683) | 0.247 (0.108, 1.097) | 0.174 (0.115, 0.344) | 0.187 (0.102, 0.662) | 0.183 (0.091, 0.489) | 0.161 (0.107, 0.372) | ||||||||||
| Taxel_therapies | count | 40 | 40 | 40 | 40 | 40 | 40 | 40 | 40 | |||||||||
| time | 26 (20, 34) | 26 (20, 34) | 26 (20, 34) | 26 (20, 34) | 26 (20, 34) | 26 (20, 34) | 26 (20, 34) | 26 (20, 34) | ||||||||||
| n | 6 (2, 17) | 5 (2, 10) | 2 (1, 5) | 2 (0, 5) | 4 (1, 8) | 3 (1, 6) | 2 (1, 8) | 2 (1, 5) | ||||||||||
| post_p | 0.32 (0.19, 0.45) | 0.31 (0.17, 0.45) | 0.35 (0.18, 0.46) | 0.34 (0.21, 0.48) | 0.36 (0.19, 0.47) | 0.38 (0.28, 0.48) | 0.36 (0.25, 0.48) | 0.38 (0.26, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.124 (0.088, 0.226) | 0.129 (0.087, 0.253) | 0.204 (0.108, 0.612) | 0.243 (0.125, 1.44) | 0.187 (0.133, 0.446) | 0.164 (0.106, 0.534) | 0.168 (0.109, 0.709) | 0.217 (0.117, 0.516) | ||||||||||
| TEfus+ | Carboplatin | count | 42 | 42 | 42 | 42 | 42 | 42 | 42 | 42 | ||||||||
| time | 20 (15, 35) | 20 (15, 35) | 20 (15, 35) | 20 (15, 35) | 20 (15, 35) | 20 (15, 35) | 20 (15, 35) | 20 (15, 35) | ||||||||||
| n | 4 (1, 9) | 6 (4, 16) | 6 (2, 11) | 4 (1, 6) | 3 (1, 7) | 3 (1, 8) | 3 (1, 7) | 3 (1, 7) | ||||||||||
| post_p | 0.3 (0.18, 0.45) | 0.34 (0.16, 0.47) | 0.35 (0.14, 0.47) | 0.35 (0.19, 0.47) | 0.37 (0.24, 0.46) | 0.35 (0.2, 0.45) | 0.36 (0.23, 0.48) | 0.37 (0.17, 0.46) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.151 (0.076, 0.416) | 0.157 (0.107, 0.311) | 0.126 (0.086, 0.255) | 0.155 (0.115, 0.539) | 0.168 (0.096, 0.699) | 0.185 (0.119, 0.786) | 0.181 (0.108, 0.615) | 0.173 (0.105, 0.318) | ||||||||||
| Hormone_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 26 (19, 28) | 26 (19, 28) | 26 (19, 28) | 26 (19, 28) | 26 (19, 28) | 26 (19, 28) | 26 (19, 28) | 26 (19, 28) | ||||||||||
| n | 4 (2, 4) | 9 (5, 18) | 1 (0, 2) | 2 (1, 2) | 4 (3, 8) | 3 (2, 5) | 4 (3, 4) | 2 (1, 4) | ||||||||||
| post_p | 0.36 (0.35, 0.4) | 0.22 (0.18, 0.39) | 0.44 (0.39, 0.49) | 0.34 (0.25, 0.42) | 0.38 (0.18, 0.46) | 0.46 (0.25, 0.47) | 0.42 (0.28, 0.43) | 0.36 (0.31, 0.44) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.124 (0.091, 0.141) | 0.153 (0.107, 0.333) | 0.12 (0.103, 0.137) | 0.827 (0.387, 0.924) | 0.169 (0.143, 0.272) | 0.211 (0.156, 0.542) | 0.151 (0.11, 0.227) | 0.166 (0.11, 3.035) | ||||||||||
| Niraparib | count | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | |||||||||
| time | 22 (16, 34) | 22 (16, 34) | 22 (16, 34) | 22 (16, 34) | 22 (16, 34) | 22 (16, 34) | 22 (16, 34) | 22 (16, 34) | ||||||||||
| n | 4 (1, 14) | 8 (4, 22) | 5 (3, 10) | 3 (1, 7) | 3 (1, 6) | 4 (2, 8) | 4 (1, 8) | 4 (1, 8) | ||||||||||
| post_p | 0.37 (0.13, 0.45) | 0.38 (0.15, 0.48) | 0.25 (0.13, 0.46) | 0.38 (0.18, 0.48) | 0.37 (0.22, 0.47) | 0.4 (0.19, 0.49) | 0.33 (0.16, 0.49) | 0.34 (0.22, 0.49) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.146 (0.085, 0.747) | 0.14 (0.102, 0.285) | 0.155 (0.095, 0.413) | 0.176 (0.11, 0.449) | 0.206 (0.118, 0.654) | 0.171 (0.095, 0.338) | 0.136 (0.091, 1.132) | 0.164 (0.096, 0.579) | ||||||||||
| Taxel_therapies | count | 48 | 48 | 48 | 48 | 48 | 48 | 48 | 48 | |||||||||
| time | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | 20 (12, 32) | ||||||||||
| n | 4 (2, 12) | 10 (5, 21) | 4 (1, 9) | 2 (0, 5) | 5 (3, 10) | 5 (2, 10) | 2 (0, 7) | 2 (0, 4) | ||||||||||
| post_p | 0.31 (0.13, 0.45) | 0.32 (0.1, 0.47) | 0.33 (0.12, 0.45) | 0.35 (0.25, 0.48) | 0.39 (0.23, 0.48) | 0.34 (0.16, 0.47) | 0.35 (0.24, 0.47) | 0.35 (0.2, 0.47) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.161 (0.077, 0.337) | 0.146 (0.111, 0.238) | 0.164 (0.106, 0.568) | 0.188 (0.111, 1.131) | 0.137 (0.104, 0.346) | 0.15 (0.101, 0.458) | 0.19 (0.105, 0.643) | 0.195 (0.079, 0.768) | ||||||||||
| TP53- & AR- | Carboplatin | count | 391 | 391 | 391 | 391 | ||||||||||||
| time | 20 (13, 31) | 20 (13, 31) | 20 (13, 31) | 20 (13, 31) | ||||||||||||||
| n | 18 (8, 56) | 5 (1, 14) | 7 (3, 15) | 7 (3, 15) | ||||||||||||||
| post_p | 0.18 (0.03, 0.45) | 0.34 (0.16, 0.48) | 0.33 (0.13, 0.47) | 0.35 (0.13, 0.48) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.115 (0.084, 0.182) | 0.132 (0.081, 0.383) | 0.126 (0.083, 0.309) | 0.126 (0.081, 0.274) | ||||||||||||||
| Hormone_therapies | count | 2 | 2 | 2 | 2 | |||||||||||||
| time | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | 6 (6, 7) | ||||||||||||||
| n | 24 (22, 25) | 2 (2, 3) | 0 (0, 1) | 1 (0, 2) | ||||||||||||||
| post_p | 0.4 (0.36, 0.45) | 0.12 (0.05, 0.19) | 0.49 (0.49, 0.49) | 0.19 (0.19, 0.19) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.071 (0.056, 0.085) | 0.766 (0.7, 0.832) | 0 (0, 0) | 0.177 (0.177, 0.177) | ||||||||||||||
| Niraparib | count | 382 | 382 | 382 | 382 | |||||||||||||
| time | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | 21 (13, 32) | ||||||||||||||
| n | 18 (8, 59) | 5 (2, 15) | 7 (2, 15) | 7 (3, 16) | ||||||||||||||
| post_p | 0.18 (0.03, 0.45) | 0.33 (0.13, 0.47) | 0.33 (0.1, 0.48) | 0.33 (0.13, 0.48) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.115 (0.083, 0.19) | 0.138 (0.082, 0.428) | 0.132 (0.088, 0.34) | 0.129 (0.081, 0.34) | ||||||||||||||
| Taxel_therapies | count | 396 | 396 | 396 | 396 | |||||||||||||
| time | 21 (13, 33) | 21 (13, 33) | 21 (13, 33) | 21 (13, 33) | ||||||||||||||
| n | 19 (8, 59) | 6 (3, 16) | 6 (2, 15) | 5 (2, 14) | ||||||||||||||
| post_p | 0.16 (0.02, 0.41) | 0.28 (0.1, 0.46) | 0.35 (0.15, 0.48) | 0.35 (0.17, 0.48) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.117 (0.086, 0.197) | 0.137 (0.086, 0.317) | 0.132 (0.079, 0.428) | 0.127 (0.08, 0.39) | ||||||||||||||
| TP53+ | Carboplatin | count | 35 | 35 | 35 | 35 | 35 | 35 | 35 | 35 | ||||||||
| time | 20 (13, 35) | 20 (13, 35) | 20 (13, 35) | 20 (13, 35) | 20 (13, 35) | 20 (13, 35) | 20 (13, 35) | 20 (13, 35) | ||||||||||
| n | 11 (6, 20) | 6 (2, 13) | 3 (1, 7) | 4 (2, 8) | 3 (2, 11) | 3 (1, 8) | 2 (1, 8) | 3 (1, 6) | ||||||||||
| post_p | 0.28 (0.09, 0.47) | 0.33 (0.16, 0.47) | 0.34 (0.19, 0.48) | 0.41 (0.26, 0.49) | 0.35 (0.19, 0.49) | 0.35 (0.13, 0.47) | 0.38 (0.19, 0.49) | 0.34 (0.14, 0.46) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.146 (0.11, 0.227) | 0.143 (0.104, 0.516) | 0.207 (0.122, 1.072) | 0.155 (0.097, 0.268) | 0.151 (0.095, 0.33) | 0.198 (0.1, 0.814) | 0.168 (0.094, 1.099) | 0.247 (0.095, 0.766) | ||||||||||
| Hormone_therapies | count | 29 | 29 | 29 | 29 | 29 | 29 | 29 | 29 | |||||||||
| time | 20 (11, 29) | 20 (11, 29) | 20 (11, 29) | 20 (11, 29) | 20 (11, 29) | 20 (11, 29) | 20 (11, 29) | 20 (11, 29) | ||||||||||
| n | 14 (6, 29) | 8 (3, 15) | 2 (0, 3) | 2 (1, 5) | 3 (1, 7) | 3 (1, 7) | 2 (0, 4) | 2 (1, 4) | ||||||||||
| post_p | 0.28 (0.09, 0.42) | 0.36 (0.12, 0.48) | 0.33 (0.18, 0.49) | 0.42 (0.28, 0.47) | 0.31 (0.22, 0.44) | 0.32 (0.18, 0.49) | 0.35 (0.15, 0.47) | 0.34 (0.21, 0.47) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.146 (0.112, 0.236) | 0.157 (0.091, 0.344) | 0.239 (0.117, 0.493) | 0.17 (0.044, 1.247) | 0.227 (0.142, 1.247) | 0.196 (0.104, 0.456) | 0.416 (0.075, 0.955) | 0.228 (0.094, 1.164) | ||||||||||
| Niraparib | count | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | |||||||||
| time | 19 (12, 33) | 19 (12, 33) | 19 (12, 33) | 19 (12, 33) | 19 (12, 33) | 19 (12, 33) | 19 (12, 33) | 19 (12, 33) | ||||||||||
| n | 10 (5, 40) | 6 (4, 19) | 3 (1, 8) | 2 (1, 9) | 3 (0, 7) | 3 (1, 5) | 3 (2, 6) | 3 (1, 7) | ||||||||||
| post_p | 0.24 (0.12, 0.49) | 0.38 (0.16, 0.46) | 0.35 (0.18, 0.47) | 0.33 (0.22, 0.48) | 0.35 (0.23, 0.46) | 0.38 (0.24, 0.48) | 0.4 (0.22, 0.49) | 0.35 (0.15, 0.48) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.159 (0.114, 0.416) | 0.131 (0.1, 0.333) | 0.166 (0.108, 1.105) | 0.234 (0.116, 0.635) | 0.168 (0.13, 0.55) | 0.184 (0.12, 0.664) | 0.181 (0.109, 0.324) | 0.165 (0.093, 0.544) | ||||||||||
| Taxel_therapies | count | 29 | 29 | 29 | 29 | 29 | 29 | 29 | 29 | |||||||||
| time | 22 (9, 33) | 22 (9, 33) | 22 (9, 33) | 22 (9, 33) | 22 (9, 33) | 22 (9, 33) | 22 (9, 33) | 22 (9, 33) | ||||||||||
| n | 11 (5, 27) | 10 (5, 16) | 2 (0, 5) | 2 (0, 4) | 4 (1, 11) | 4 (2, 8) | 2 (0, 5) | 2 (1, 5) | ||||||||||
| post_p | 0.34 (0.17, 0.46) | 0.25 (0.13, 0.43) | 0.31 (0.19, 0.43) | 0.4 (0.28, 0.49) | 0.38 (0.19, 0.46) | 0.35 (0.14, 0.48) | 0.33 (0.21, 0.45) | 0.36 (0.22, 0.49) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.143 (0.103, 0.246) | 0.15 (0.108, 0.197) | 0.292 (0.148, 0.545) | 0.18 (0.108, 0.793) | 0.174 (0.124, 0.523) | 0.137 (0.07, 0.462) | 0.205 (0.02, 0.733) | 0.196 (0.107, 0.78) |