Simulation scenario 4

Setting description

Hormone_therapies more effective in the TP53- & AR- biomarker signature

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.094, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 10.4, median = 7.5	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1.18, hr = 0.84	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.094, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 10.4, median = 7.5	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1.18, hr = 0.84	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.094, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 10.4, median = 7.5	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1.18, hr = 0.84	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 35 4 2 2 TP53- & AR- 405 1 1 3 TP53+ 3 9 3 4 DRD+ 7 0 1 2 TEfus+ 10 3 2 3

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.070 0.008 0.004 0.004 TP53- & AR- 0.810 0.002 0.002 0.006 TP53+ 0.006 0.018 0.006 0.008 DRD+ 0.014 0.000 0.002 0.004 TEfus+ 0.020 0.006 0.004 0.006

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 1 3 2 3 TP53- & AR- 2 396 391 382 TP53+ 29 29 35 30 DRD+ 2 40 41 42 TEfus+ 3 48 42 30

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.002 0.006 0.004 0.006 TP53- & AR- 0.004 0.792 0.782 0.764 TP53+ 0.058 0.058 0.070 0.060 DRD+ 0.004 0.080 0.082 0.084 TEfus+ 0.006 0.096 0.084 0.060

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 49 11 16 27 TP53+ 10 12 8 9 DRD+ 0 0 0 0 TEfus+ 0 0 0 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.098 0.022 0.032 0.054 TP53+ 0.020 0.024 0.016 0.018 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.000 0.000

Errors & power

The overall error was 0.132.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.062             0.034             0.016             0.028 

The overall power was 0.81.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
             0.81              0.00              0.00              0.00 

Median results at the end of the trial

By signature:

signature	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
all	graduation	2	0	35	2	4
	futility	2	0	1	3	3
	max_n	0	0	0	0	0
	n	166 (119, 235)	418 (351, 460)	158 (95, 262)	167 (122, 252)	168 (120, 246)
	n_unique	152 (109, 219)	386 (324, 426)	145 (88, 246)	155 (111, 237)	155 (111, 230)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	7 (6, 11)	NA (NA, NA)	4 (3, 6)	22 (6, 28)	6 (4, 6)
	post_p	0.05 (0, 0.29)	NA (NA, NA)	0.97 (0.64, 1)	0.05 (0, 0.34)	0.04 (0, 0.29)
	rate	0.113 (0.102, 0.126)	0.094 (0.087, 0.102)	0.078 (0.06, 0.09)	0.112 (0.101, 0.126)	0.113 (0.102, 0.128)
DRD+	graduation	1	0	7	2	0
	futility	41	0	2	42	40
	max_n	0	0	0	0	0
	n	58 (39, 81)	112 (92, 128)	37 (18, 58)	58 (37, 80)	47 (26, 70)
	n_unique	53 (35, 74)	102 (84, 118)	33 (17, 53)	53 (33, 73)	43 (24, 65)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	24 (15, 34)	NA (NA, NA)	26 (20, 29)	24 (14, 34)	26 (20, 34)
	post_p	0.2 (0.02, 0.67)	NA (NA, NA)	0.62 (0.18, 0.95)	0.19 (0.02, 0.68)	0.26 (0.04, 0.71)
	rate	0.114 (0.094, 0.141)	0.097 (0.083, 0.113)	0.091 (0.068, 0.125)	0.115 (0.096, 0.143)	0.112 (0.093, 0.146)
TEfus+	graduation	2	0	10	3	3
	futility	42	0	3	30	48
	max_n	0	0	0	0	0
	n	68 (42, 97)	151 (127, 173)	59 (28, 88)	69 (45, 98)	71 (42, 100)
	n_unique	62 (39, 89)	138 (117, 158)	55 (26, 80)	64 (40, 90)	66 (39, 92)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (35, 36)
	time_stop	20 (15, 35)	NA (NA, NA)	16 (12, 28)	21 (14, 34)	20 (11, 32)
	post_p	0.27 (0.04, 0.73)	NA (NA, NA)	0.72 (0.24, 0.97)	0.27 (0.03, 0.68)	0.24 (0.04, 0.7)
	rate	0.113 (0.096, 0.135)	0.1 (0.088, 0.113)	0.092 (0.072, 0.115)	0.112 (0.096, 0.139)	0.114 (0.097, 0.139)
TP53- & AR-	graduation	1	0	405	3	1
	futility	391	0	2	382	396
	max_n	16	0	49	27	11
	n	44 (26, 122)	177 (109, 206)	34 (25, 150)	46 (25, 134)	41 (25, 120)
	n_unique	40 (23, 114)	165 (98, 193)	32 (24, 141)	42 (23, 127)	36 (23, 111)
	time_trial	23 (14, 36)	36 (36, 36)	10 (7, 36)	24 (14, 36)	25 (14, 36)
	time_stop	20 (13, 31)	NA (NA, NA)	9 (6, 20)	21 (13, 32)	21 (13, 33)
	post_p	0.01 (0, 0.15)	NA (NA, NA)	1 (0.97, 1)	0.02 (0, 0.12)	0.01 (0, 0.12)
	rate	0.115 (0.095, 0.143)	0.075 (0.064, 0.084)	0.041 (0.031, 0.051)	0.114 (0.097, 0.145)	0.116 (0.098, 0.152)
TP53+	graduation	3	0	3	4	9
	futility	35	0	29	30	29
	max_n	8	0	10	9	12
	n	82 (54, 119)	184 (162, 210)	84 (33, 122)	86 (51, 126)	89 (53, 127)
	n_unique	76 (49, 111)	170 (148, 194)	76 (31, 114)	79 (47, 117)	81 (49, 118)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	20 (13, 35)	NA (NA, NA)	19 (11, 29)	19 (11, 32)	15 (8, 31)
	post_p	0.49 (0.1, 0.9)	NA (NA, NA)	0.52 (0.09, 0.89)	0.51 (0.1, 0.88)	0.53 (0.11, 0.9)
	rate	0.113 (0.097, 0.138)	0.113 (0.101, 0.124)	0.112 (0.096, 0.137)	0.113 (0.097, 0.135)	0.112 (0.097, 0.135)

By subgroup combinations:

subtype	var	Carboplatin	Control	Hormone_therapies	Niraparib	Taxel_therapies
—-	graduation	396	0	439	387	404
	futility	0	0	0	0	0
	max_n	16	0	49	27	11
	n	19 (8, 74)	114 (70, 136)	27 (19, 107)	22 (8, 83)	21 (8, 76)
	n_unique	18 (7, 71)	106 (62, 128)	25 (17, 103)	20 (7, 79)	19 (7, 72)
	post_p	0.08 (0.01, 0.31)	NA (NA, NA)	1 (0.93, 1)	0.07 (0, 0.32)	0.06 (0.01, 0.3)
	rate	0.117 (0.09, 0.173)	0.074 (0.064, 0.087)	0.041 (0.03, 0.053)	0.116 (0.09, 0.18)	0.119 (0.093, 0.183)
—+	graduation	403	0	439	389	409
	futility	0	0	0	0	0
	max_n	16	0	49	27	11
	n	6 (2, 17)	20 (12, 28)	4 (2, 14)	6 (2, 19)	7 (3, 17)
	n_unique	5 (1, 16)	18 (10, 26)	4 (1, 13)	6 (2, 17)	6 (2, 16)
	post_p	0.3 (0.12, 0.61)	NA (NA, NA)	0.83 (0.45, 0.98)	0.27 (0.09, 0.57)	0.24 (0.08, 0.52)
	rate	0.127 (0.075, 0.328)	0.076 (0.051, 0.11)	0.044 (0.018, 0.096)	0.127 (0.077, 0.342)	0.136 (0.083, 0.299)
–+-	graduation	41	0	68	36	45
	futility	0	0	0	0	0
	max_n	8	0	10	9	12
	n	22 (7, 52)	62 (49, 77)	26 (8, 56)	24 (6, 54)	26 (8, 57)
	n_unique	20 (6, 50)	57 (45, 72)	24 (7, 52)	22 (5, 50)	23 (7, 54)
	post_p	0.43 (0.11, 0.85)	NA (NA, NA)	0.46 (0.1, 0.87)	0.42 (0.11, 0.86)	0.45 (0.12, 0.88)
	rate	0.12 (0.092, 0.206)	0.112 (0.094, 0.136)	0.118 (0.09, 0.191)	0.118 (0.091, 0.211)	0.117 (0.088, 0.202)
–++	graduation	76	0	79	66	88
	futility	0	0	0	0	0
	max_n	8	0	10	9	12
	n	14 (4, 34)	41 (32, 53)	17 (4, 36)	14 (5, 35)	18 (7, 41)
	n_unique	12 (3, 31)	38 (29, 50)	15 (3, 34)	14 (4, 33)	17 (6, 39)
	post_p	0.45 (0.15, 0.85)	NA (NA, NA)	0.49 (0.15, 0.87)	0.44 (0.14, 0.83)	0.48 (0.13, 0.87)
	rate	0.119 (0.085, 0.276)	0.113 (0.09, 0.143)	0.119 (0.082, 0.227)	0.121 (0.086, 0.228)	0.117 (0.089, 0.195)
-+–	graduation	401	0	439	394	407
	futility	0	0	0	0	0
	max_n	16	0	49	26	11
	n	8 (3, 20)	19 (11, 27)	2 (0, 11)	8 (3, 19)	7 (2, 17)
	n_unique	7 (3, 18)	18 (10, 25)	1 (0, 11)	7 (2, 18)	6 (1, 16)
	post_p	0.25 (0.09, 0.58)	NA (NA, NA)	0.78 (0.42, 0.96)	0.27 (0.09, 0.58)	0.3 (0.11, 0.62)
	rate	0.126 (0.079, 0.281)	0.076 (0.052, 0.11)	0.043 (0, 0.129)	0.127 (0.08, 0.301)	0.126 (0.078, 0.363)
-+-+	graduation	407	0	439	395	412
	futility	0	0	0	0	0
	max_n	16	0	49	26	11
	n	8 (3, 19)	20 (12, 28)	2 (0, 11)	8 (3, 20)	6 (2, 18)
	n_unique	7 (3, 17)	18 (11, 26)	2 (0, 11)	7 (3, 18)	5 (2, 17)
	post_p	0.26 (0.1, 0.58)	NA (NA, NA)	0.75 (0.4, 0.96)	0.25 (0.08, 0.56)	0.3 (0.11, 0.6)
	rate	0.122 (0.081, 0.259)	0.074 (0.052, 0.109)	0.049 (0.015, 0.135)	0.129 (0.085, 0.302)	0.125 (0.078, 0.308)
-++-	graduation	74	0	77	71	76
	futility	0	0	0	0	0
	max_n	8	0	10	9	12
	n	6 (2, 13)	12 (7, 17)	4 (1, 11)	6 (2, 12)	4 (1, 11)
	n_unique	5 (2, 12)	11 (7, 16)	4 (1, 10)	6 (2, 11)	4 (1, 10)
	post_p	0.46 (0.2, 0.8)	NA (NA, NA)	0.47 (0.22, 0.82)	0.44 (0.21, 0.82)	0.45 (0.23, 0.81)
	rate	0.135 (0.074, 0.391)	0.117 (0.073, 0.179)	0.13 (0.063, 0.45)	0.131 (0.071, 0.323)	0.132 (0.066, 0.418)
-+++	graduation	102	0	88	97	113
	futility	0	0	0	0	0
	max_n	8	0	10	9	12
	n	6 (2, 13)	12 (7, 18)	4 (1, 10)	6 (2, 13)	4 (1, 10)
	n_unique	5 (2, 12)	11 (6, 16)	4 (1, 9)	5 (2, 12)	4 (1, 9)
	post_p	0.44 (0.23, 0.82)	NA (NA, NA)	0.47 (0.23, 0.82)	0.44 (0.2, 0.84)	0.46 (0.22, 0.82)
	rate	0.139 (0.07, 0.322)	0.118 (0.078, 0.175)	0.129 (0.065, 0.383)	0.137 (0.072, 0.396)	0.132 (0.068, 0.431)
+—	graduation	4	0	36	5	7
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	8 (3, 17)	20 (14, 27)	8 (2, 18)	8 (2, 18)	10 (4, 20)
	n_unique	7 (3, 16)	18 (12, 25)	7 (2, 17)	7 (2, 16)	9 (3, 19)
	post_p	0.48 (0.19, 0.85)	NA (NA, NA)	0.48 (0.2, 0.84)	0.44 (0.19, 0.85)	0.45 (0.15, 0.83)
	rate	0.12 (0.075, 0.283)	0.113 (0.085, 0.169)	0.125 (0.074, 0.265)	0.125 (0.075, 0.308)	0.124 (0.08, 0.305)
+–+	graduation	48	0	49	36	58
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	6 (2, 15)	16 (10, 22)	6 (2, 15)	6 (2, 15)	8 (3, 17)
	n_unique	6 (2, 14)	15 (10, 21)	6 (1, 14)	6 (2, 14)	7 (2, 15)
	post_p	0.47 (0.21, 0.83)	NA (NA, NA)	0.45 (0.2, 0.82)	0.46 (0.21, 0.83)	0.43 (0.17, 0.85)
	rate	0.124 (0.07, 0.343)	0.114 (0.083, 0.162)	0.128 (0.075, 0.334)	0.127 (0.071, 0.392)	0.13 (0.079, 0.321)
+-+-	graduation	41	0	68	36	45
	futility	0	0	0	0	0
	max_n	8	0	10	9	12
	n	6 (2, 14)	16 (11, 23)	6 (2, 14)	7 (2, 15)	8 (3, 16)
	n_unique	5 (2, 13)	15 (9, 21)	5 (1, 13)	6 (2, 14)	7 (3, 16)
	post_p	0.48 (0.21, 0.84)	NA (NA, NA)	0.43 (0.2, 0.81)	0.48 (0.22, 0.84)	0.45 (0.19, 0.82)
	rate	0.122 (0.071, 0.332)	0.116 (0.081, 0.17)	0.133 (0.073, 0.34)	0.125 (0.07, 0.293)	0.127 (0.081, 0.281)
+-++	graduation	76	0	79	66	88
	futility	0	0	0	0	0
	max_n	8	0	10	9	12
	n	6 (2, 15)	16 (10, 22)	6 (1, 15)	6 (2, 14)	7 (2, 17)
	n_unique	6 (2, 14)	14 (10, 20)	5 (1, 13)	6 (2, 14)	7 (2, 16)
	post_p	0.49 (0.21, 0.83)	NA (NA, NA)	0.44 (0.2, 0.8)	0.48 (0.2, 0.82)	0.45 (0.19, 0.81)
	rate	0.122 (0.073, 0.362)	0.113 (0.081, 0.166)	0.127 (0.074, 0.392)	0.122 (0.068, 0.358)	0.128 (0.081, 0.312)
++–	graduation	45	0	45	47	47
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	6 (2, 13)	11 (7, 16)	4 (1, 10)	6 (2, 12)	4 (1, 10)
	n_unique	6 (2, 12)	10 (6, 15)	4 (1, 9)	5 (2, 11)	4 (1, 10)
	post_p	0.49 (0.21, 0.83)	NA (NA, NA)	0.46 (0.23, 0.8)	0.45 (0.19, 0.83)	0.46 (0.22, 0.78)
	rate	0.123 (0.069, 0.339)	0.116 (0.074, 0.181)	0.13 (0.067, 0.381)	0.133 (0.073, 0.383)	0.129 (0.068, 0.39)
++-+	graduation	77	0	58	73	91
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	6 (2, 13)	11 (7, 17)	4 (1, 10)	6 (2, 13)	4 (1, 11)
	n_unique	5 (2, 12)	10 (6, 16)	3 (1, 9)	6 (2, 13)	4 (1, 10)
	post_p	0.47 (0.2, 0.82)	NA (NA, NA)	0.46 (0.22, 0.8)	0.47 (0.21, 0.85)	0.46 (0.23, 0.82)
	rate	0.128 (0.074, 0.373)	0.116 (0.075, 0.177)	0.132 (0.07, 0.493)	0.125 (0.07, 0.392)	0.132 (0.07, 0.428)
+++-	graduation	74	0	77	71	76
	futility	0	0	0	0	0
	max_n	8	0	10	9	12
	n	6 (2, 12)	11 (7, 17)	4 (1, 10)	6 (2, 13)	4 (1, 11)
	n_unique	5 (2, 12)	10 (6, 16)	4 (1, 9)	5 (2, 12)	4 (1, 10)
	post_p	0.45 (0.2, 0.83)	NA (NA, NA)	0.48 (0.21, 0.82)	0.44 (0.2, 0.81)	0.46 (0.24, 0.83)
	rate	0.126 (0.07, 0.333)	0.111 (0.074, 0.176)	0.124 (0.065, 0.421)	0.131 (0.074, 0.388)	0.127 (0.063, 0.503)
++++	graduation	102	0	88	97	113
	futility	0	0	0	0	0
	max_n	8	0	10	9	12
	n	6 (2, 13)	12 (7, 17)	4 (1, 11)	6 (2, 12)	4 (1, 11)
	n_unique	5 (2, 12)	11 (7, 16)	4 (1, 10)	5 (2, 11)	4 (1, 10)
	post_p	0.43 (0.19, 0.85)	NA (NA, NA)	0.44 (0.23, 0.81)	0.46 (0.2, 0.81)	0.47 (0.23, 0.81)
	rate	0.132 (0.07, 0.359)	0.115 (0.073, 0.175)	0.131 (0.065, 0.438)	0.125 (0.071, 0.382)	0.127 (0.062, 0.422)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	35	4	2	2
	time_stop	4 (3, 7)	6 (5, 7)	6 (6, 7)	6 (5, 8)
	n_trt	29 (26, 49)	38 (28, 43)	28 (26, 30)	31 (28, 34)
	n_control	49 (40, 71)	70 (52, 78)	76 (68, 84)	67 (56, 78)
	post_p	0.94 (0.88, 0.98)	0.92 (0.9, 0.95)	0.98 (0.98, 0.98)	0.91 (0.88, 0.95)
	order	1 (1, 1)	1 (1, 1)	1.5 (1.1, 1.9)	1 (1, 1)
TP53- & AR-	count	405	1	1	3
	time_stop	9 (6, 21)	11 (11, 11)	8 (8, 8)	13 (10, 15)
	n_trt	33 (26, 79)	27 (27, 27)	25 (25, 25)	26 (25, 48)
	n_control	41 (28, 104)	37 (37, 37)	37 (37, 37)	58 (39, 79)
	post_p	0.95 (0.87, 1)	0.96 (0.96, 0.96)	0.85 (0.85, 0.85)	0.9 (0.88, 0.95)
	order	1 (1, 1)	1 (1, 1)	2 (2, 2)	2 (1.2, 2)
TP53+	count	3	9	3	4
	time_stop	12 (10, 14)	9 (7, 13)	11 (9, 13)	16 (10, 20)
	n_trt	42 (30, 46)	29 (26, 40)	33 (28, 40)	40 (29, 52)
	n_control	44 (35, 70)	42 (31, 71)	57 (43, 59)	70 (47, 90)
	post_p	0.94 (0.94, 0.97)	0.96 (0.91, 0.98)	0.97 (0.89, 0.99)	0.98 (0.94, 1)
	order	2 (1.2, 2)	1 (1, 2.2)	2 (1.2, 2)	1.5 (1, 2)
DRD+	count	7		1	2
	time_stop	26 (20, 30)		10 (10, 10)	12 (9, 14)
	n_trt	26 (25, 34)		25 (25, 25)	31 (27, 35)
	n_control	80 (55, 86)		29 (29, 29)	36 (30, 42)
	post_p	0.95 (0.93, 0.99)		0.92 (0.92, 0.92)	0.9 (0.88, 0.91)
	order	2 (2, 2.4)		2 (2, 2)	1 (1, 1)
TEfus+	count	10	3	2	3
	time_stop	15 (12, 23)	11 (8, 13)	12 (10, 14)	12 (11, 13)
	n_trt	28 (25, 36)	25 (25, 35)	28 (27, 29)	29 (28, 29)
	n_control	56 (43, 85)	46 (30, 54)	58 (47, 70)	45 (39, 50)
	post_p	0.98 (0.93, 1)	0.94 (0.89, 0.94)	0.96 (0.96, 0.96)	0.92 (0.9, 0.92)
	order	2 (2, 2.1)	2 (1.2, 2)	2.5 (2.1, 2.9)	2 (2, 2)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	1	3	2	3
	time_stop	3 (3, 3)	5 (3, 6)	10 (8, 12)	28 (23, 28)
	n_trt	26 (26, 26)	28 (26, 38)	44 (29, 58)	107 (85, 167)
	n_control	31 (31, 31)	56 (38, 63)	105 (84, 126)	332 (268, 347)
	post_p	0.15 (0.15, 0.15)	0.08 (0.06, 0.17)	0.02 (0.01, 0.04)	0 (0, 0.01)
	order	1 (1, 1)	1 (1, 1)	1 (1, 1)	4 (2.4, 6.4)
TP53- & AR-	count	2	396	391	382
	time_stop	6 (6, 7)	21 (13, 33)	20 (13, 31)	21 (13, 32)
	n_trt	28 (26, 29)	36 (25, 94)	38 (26, 87)	35 (25, 96)
	n_control	33 (32, 34)	107 (57, 178)	101 (59, 165)	104 (58, 174)
	post_p	0.15 (0.13, 0.18)	0.05 (0, 0.2)	0.06 (0, 0.2)	0.05 (0, 0.18)
	order	1 (1, 1)	2 (1, 4)	2 (1, 3)	2 (1, 4)
TP53+	count	29	29	35	30
	time_stop	20 (11, 29)	22 (9, 33)	20 (13, 35)	19 (12, 33)
	n_trt	34 (27, 62)	37 (26, 76)	38 (26, 61)	36 (26, 67)
	n_control	95 (40, 148)	107 (44, 164)	101 (60, 181)	94 (53, 170)
	post_p	0.04 (0, 0.19)	0.06 (0, 0.16)	0.05 (0.01, 0.14)	0.05 (0.01, 0.15)
	order	2 (1, 4)	2 (1, 5)	2 (1, 5)	3 (1, 5)
DRD+	count	2	40	41	42
	time_stop	26 (24, 27)	26 (20, 34)	24 (16, 34)	26 (14, 34)
	n_trt	26 (25, 27)	29 (25, 44)	39 (27, 54)	36 (26, 52)
	n_control	82 (78, 86)	78 (55, 114)	70 (45, 105)	78 (42, 106)
	post_p	0.04 (0.02, 0.07)	0.04 (0, 0.17)	0.04 (0.01, 0.14)	0.04 (0.01, 0.1)
	order	3.5 (2.3, 4.7)	4 (1, 5)	3 (2, 5)	3 (1, 5)
TEfus+	count	3	48	42	30
	time_stop	26 (19, 28)	20 (12, 32)	20 (15, 35)	22 (16, 34)
	n_trt	29 (27, 36)	38 (26, 63)	36 (26, 58)	42 (28, 60)
	n_control	121 (72, 126)	81 (41, 138)	90 (56, 148)	88 (54, 140)
	post_p	0.12 (0.05, 0.14)	0.04 (0.01, 0.15)	0.05 (0.01, 0.12)	0.05 (0.01, 0.19)
	order	3 (1.4, 3.8)	2.5 (1, 4.3)	3 (1, 5)	3 (1, 6.1)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Carboplatin	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)	6 (6, 7)
		n	4 (3, 4)	1 (1, 1)	3 (1, 5)	0 (0, 0)	4 (4, 4)	0 (0, 1)	2 (2, 3)	2 (2, 2)	0 (0, 1)	2 (1, 4)	2 (2, 3)	1 (1, 1)	2 (2, 2)	1 (0, 2)	1 (0, 2)	2 (1, 2)
		post_p	0.59 (0.57, 0.6)	0.56 (0.56, 0.56)	0.59 (0.54, 0.64)	NA (NA, NA)	0.72 (0.71, 0.73)	0.57 (0.57, 0.57)	0.52 (0.52, 0.52)	0.56 (0.53, 0.58)	0.5 (0.5, 0.5)	0.53 (0.52, 0.53)	0.63 (0.58, 0.68)	0.51 (0.5, 0.52)	0.77 (0.76, 0.78)	0.51 (0.51, 0.51)	0.76 (0.76, 0.76)	0.63 (0.58, 0.68)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	0 (0, 0)	0.037 (0.007, 0.066)	NA (NA, NA)	0.031 (0.006, 0.056)	0 (0, 0)	0.043 (0.009, 0.078)	0.152 (0.03, 0.273)	0 (0, 0)	0.074 (0.015, 0.133)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Hormone_therapies	count	35	35	35	35	35	35	35	35	35	35	35	35	35	35	35	35
		time	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)	4 (3, 7)
		n	15 (12, 22)	2 (1, 6)	6 (3, 10)	2 (0, 7)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	1 (0, 2)	1 (0, 3)	0 (0, 2)	0 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)
		post_p	0.76 (0.64, 0.9)	0.63 (0.54, 0.71)	0.65 (0.54, 0.77)	0.59 (0.52, 0.73)	0.54 (0.51, 0.58)	0.54 (0.53, 0.57)	0.54 (0.51, 0.56)	0.51 (0.51, 0.61)	0.6 (0.53, 0.69)	0.57 (0.51, 0.69)	0.58 (0.51, 0.64)	0.59 (0.52, 0.67)	NA (NA, NA)	0.52 (0.51, 0.52)	0.52 (0.51, 0.55)	0.52 (0.51, 0.54)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.023 (0, 0.048)	0 (0, 0.025)	0.05 (0, 0.134)	0 (0, 0.083)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.094)	0 (0, 0.108)	0 (0, 0.54)	0 (0, 0)	0 (0, 0)	0 (0, 0.205)	0 (0, 0)
	Niraparib	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)	6 (5, 8)
		n	2 (1, 3)	0 (0, 1)	6 (4, 8)	1 (1, 1)	2 (1, 3)	2 (2, 3)	3 (3, 3)	2 (2, 2)	2 (1, 3)	0 (0, 0)	0 (0, 1)	0 (0, 1)	2 (1, 3)	3 (2, 4)	2 (1, 2)	2 (2, 3)
		post_p	0.58 (0.55, 0.6)	0.56 (0.56, 0.56)	0.51 (0.51, 0.52)	0.54 (0.52, 0.56)	0.62 (0.57, 0.67)	0.63 (0.59, 0.66)	0.73 (0.71, 0.75)	0.6 (0.56, 0.64)	0.56 (0.54, 0.59)	NA (NA, NA)	0.51 (0.51, 0.51)	0.51 (0.51, 0.51)	0.63 (0.59, 0.66)	0.62 (0.62, 0.62)	0.57 (0.54, 0.59)	0.65 (0.6, 0.71)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	0 (0, 0)	0.096 (0.083, 0.108)	0 (0, 0)	0 (0, 0)	0.057 (0.011, 0.102)	0.061 (0.012, 0.111)	0.065 (0.013, 0.117)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.096 (0.019, 0.173)	0.078 (0.016, 0.14)	0.024 (0.005, 0.043)
	Taxel_therapies	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)
		n	4 (2, 8)	2 (0, 4)	6 (3, 9)	6 (4, 7)	0 (0, 2)	0 (0, 2)	0 (0, 1)	0 (0, 1)	6 (4, 6)	3 (2, 3)	3 (2, 4)	4 (2, 5)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)
		post_p	0.56 (0.54, 0.65)	0.59 (0.52, 0.66)	0.74 (0.66, 0.89)	0.66 (0.56, 0.72)	0.54 (0.52, 0.55)	0.57 (0.55, 0.58)	0.59 (0.59, 0.59)	0.51 (0.51, 0.51)	0.63 (0.54, 0.66)	0.64 (0.53, 0.75)	0.73 (0.61, 0.81)	0.59 (0.52, 0.73)	0.56 (0.56, 0.56)	0.51 (0.51, 0.51)	NA (NA, NA)	0.52 (0.52, 0.52)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.023 (0, 0.088)	0 (0, 0)	0 (0, 0.03)	0.019 (0, 0.067)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.096 (0.056, 0.172)	0.108 (0.032, 0.138)	0 (0, 0.033)	0.041 (0, 0.113)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)
DRD+	Carboplatin	count					1	1	1	1					1	1	1	1
		time					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)
		n					9 (9, 9)	4 (4, 4)	2 (2, 2)	1 (1, 1)					5 (5, 5)	3 (3, 3)	0 (0, 0)	1 (1, 1)
		post_p					0.82 (0.82, 0.82)	0.71 (0.71, 0.71)	0.58 (0.58, 0.58)	0.51 (0.51, 0.51)					0.88 (0.88, 0.88)	0.7 (0.7, 0.7)	NA (NA, NA)	0.55 (0.55, 0.55)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.08 (0.08, 0.08)	0.049 (0.049, 0.049)	0 (0, 0)	0 (0, 0)					0.085 (0.085, 0.085)	0.057 (0.057, 0.057)	NA (NA, NA)	0 (0, 0)
	Hormone_therapies	count					7	7	7	7					7	7	7	7
		time					26 (20, 30)	26 (20, 30)	26 (20, 30)	26 (20, 30)					26 (20, 30)	26 (20, 30)	26 (20, 30)	26 (20, 30)
		n					1 (0, 4)	1 (1, 8)	4 (3, 8)	3 (3, 7)					2 (2, 3)	3 (1, 4)	4 (1, 5)	4 (3, 9)
		post_p					0.74 (0.64, 0.76)	0.84 (0.64, 0.91)	0.72 (0.62, 0.87)	0.73 (0.64, 0.84)					0.6 (0.52, 0.74)	0.65 (0.52, 0.76)	0.71 (0.6, 0.84)	0.71 (0.52, 0.82)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.03 (0.007, 0.052)	0 (0, 0.057)	0.063 (0.036, 0.116)	0.057 (0.019, 0.097)					0.055 (0, 0.083)	0.09 (0.016, 0.164)	0.065 (0.047, 0.087)	0.065 (0.028, 0.108)
	Niraparib	count					2	2	2	2					2	2	2	2
		time					12 (9, 14)	12 (9, 14)	12 (9, 14)	12 (9, 14)					12 (9, 14)	12 (9, 14)	12 (9, 14)	12 (9, 14)
		n					4 (3, 4)	7 (5, 9)	5 (4, 6)	2 (2, 3)					5 (5, 5)	0 (0, 1)	4 (4, 4)	4 (3, 4)
		post_p					0.6 (0.6, 0.62)	0.72 (0.7, 0.74)	0.84 (0.76, 0.92)	0.55 (0.51, 0.59)					0.68 (0.63, 0.73)	0.52 (0.52, 0.52)	0.52 (0.52, 0.52)	0.59 (0.52, 0.66)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.042 (0.008, 0.076)	0.077 (0.07, 0.083)	0.012 (0.002, 0.021)	0.082 (0.016, 0.147)					0.04 (0.008, 0.072)	0.112 (0.112, 0.112)	0.098 (0.075, 0.121)	0.157 (0.07, 0.244)
TEfus+	Carboplatin	count		2		2		2		2		2		2		2		2
		time		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)		12 (10, 14)
		n		2 (1, 2)		4 (2, 5)		3 (3, 3)		4 (3, 5)		4 (3, 6)		2 (1, 4)		6 (3, 8)		4 (3, 4)
		post_p		0.58 (0.52, 0.64)		0.58 (0.56, 0.59)		0.6 (0.53, 0.66)		0.72 (0.67, 0.77)		0.76 (0.74, 0.79)		0.69 (0.66, 0.72)		0.81 (0.81, 0.81)		0.65 (0.65, 0.66)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0.114 (0.113, 0.115)		0.085 (0.069, 0.102)		0.018 (0.004, 0.032)		0.026 (0.005, 0.048)		0.022 (0.004, 0.039)		0.13 (0.127, 0.134)		0.048 (0.041, 0.054)
	Hormone_therapies	count		10		10		10		10		10		10		10		10
		time		15 (12, 23)		15 (12, 23)		15 (12, 23)		15 (12, 23)		15 (12, 23)		15 (12, 23)		15 (12, 23)		15 (12, 23)
		n		5 (3, 6)		6 (5, 14)		2 (1, 4)		2 (1, 4)		2 (1, 7)		5 (2, 8)		2 (0, 4)		1 (0, 4)
		post_p		0.82 (0.72, 0.9)		0.74 (0.57, 0.88)		0.73 (0.6, 0.9)		0.64 (0.5, 0.87)		0.65 (0.55, 0.78)		0.64 (0.53, 0.76)		0.57 (0.52, 0.72)		0.61 (0.56, 0.75)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.023 (0, 0.057)		0.073 (0.051, 0.109)		0 (0, 0.045)		0 (0, 0.075)		0.082 (0, 0.107)		0.076 (0, 0.114)		0.072 (0, 0.11)		0 (0, 0.074)
	Niraparib	count		3		3		3		3		3		3		3		3
		time		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)		12 (11, 13)
		n		1 (0, 3)		8 (6, 9)		4 (4, 7)		3 (1, 5)		2 (1, 3)		2 (1, 4)		3 (2, 5)		4 (4, 4)
		post_p		0.52 (0.52, 0.53)		0.73 (0.59, 0.86)		0.62 (0.56, 0.79)		0.56 (0.51, 0.62)		0.64 (0.54, 0.66)		0.62 (0.58, 0.65)		0.67 (0.55, 0.67)		0.74 (0.71, 0.77)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0.054 (0.034, 0.072)		0.048 (0.047, 0.056)		0.06 (0.012, 0.125)		0 (0, 0)		0 (0, 0.037)		0.101 (0.073, 0.285)		0.08 (0.016, 0.131)
	Taxel_therapies	count		3		3		3		3		3		3		3		3
		time		11 (8, 13)		11 (8, 13)		11 (8, 13)		11 (8, 13)		11 (8, 13)		11 (8, 13)		11 (8, 13)		11 (8, 13)
		n		2 (0, 3)		15 (12, 17)		1 (0, 4)		1 (0, 2)		3 (2, 5)		4 (2, 10)		0 (0, 0)		0 (0, 2)
		post_p		0.54 (0.51, 0.56)		0.71 (0.7, 0.83)		0.63 (0.56, 0.7)		0.59 (0.52, 0.66)		0.71 (0.63, 0.71)		0.88 (0.75, 0.93)		NA (NA, NA)		0.6 (0.6, 0.6)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.045 (0.009, 0.08)		0.063 (0.062, 0.072)		0 (0, 0)		0.032 (0.006, 0.058)		0.055 (0.011, 0.08)		0.068 (0.014, 0.076)		NA (NA, NA)		0 (0, 0)
TP53- & AR-	Carboplatin	count	1	1			1	1
		time	8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)
		n	10 (10, 10)	4 (4, 4)			7 (7, 7)	4 (4, 4)
		post_p	0.73 (0.73, 0.73)	0.58 (0.58, 0.58)			0.77 (0.77, 0.77)	0.55 (0.55, 0.55)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.048 (0.048, 0.048)	0 (0, 0)			0.033 (0.033, 0.033)	0.247 (0.247, 0.247)
	Hormone_therapies	count	405	405			405	405
		time	9 (6, 21)	9 (6, 21)			9 (6, 21)	9 (6, 21)
		n	26 (20, 58)	4 (2, 11)			1 (0, 7)	2 (0, 6)
		post_p	0.89 (0.75, 1)	0.71 (0.53, 0.85)			0.59 (0.51, 0.85)	0.6 (0.52, 0.79)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.038 (0.015, 0.055)	0.023 (0, 0.075)			0 (0, 0.059)	0 (0, 0.07)
	Niraparib	count	3	3			3	3
		time	13 (10, 15)	13 (10, 15)			13 (10, 15)	13 (10, 15)
		n	14 (13, 24)	4 (2, 6)			9 (5, 10)	4 (2, 9)
		post_p	0.78 (0.75, 0.84)	0.56 (0.53, 0.85)			0.78 (0.62, 0.9)	0.58 (0.55, 0.7)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.043 (0.009, 0.051)	0.041 (0.008, 0.042)			0.044 (0.037, 0.05)	0.043 (0.009, 0.058)
	Taxel_therapies	count	1	1			1	1
		time	11 (11, 11)	11 (11, 11)			11 (11, 11)	11 (11, 11)
		n	16 (16, 16)	4 (4, 4)			3 (3, 3)	4 (4, 4)
		post_p	0.76 (0.76, 0.76)	0.79 (0.79, 0.79)			0.72 (0.72, 0.72)	0.64 (0.64, 0.64)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.078 (0.078, 0.078)	0 (0, 0)			0 (0, 0)	0.056 (0.056, 0.056)
TP53+	Carboplatin	count			3	3			3	3			3	3			3	3
		time			11 (9, 13)	11 (9, 13)			11 (9, 13)	11 (9, 13)			11 (9, 13)	11 (9, 13)			11 (9, 13)	11 (9, 13)
		n			14 (13, 15)	5 (2, 9)			2 (0, 3)	3 (2, 4)			2 (2, 4)	1 (1, 3)			2 (0, 4)	4 (3, 4)
		post_p			0.81 (0.77, 0.89)	0.53 (0.53, 0.8)			0.63 (0.6, 0.65)	0.66 (0.57, 0.7)			0.58 (0.58, 0.62)	0.64 (0.53, 0.64)			0.59 (0.56, 0.63)	0.69 (0.63, 0.73)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.043 (0.04, 0.052)	0.091 (0.018, 0.095)			0.222 (0.112, 0.332)	0 (0, 0.09)			0.091 (0.018, 0.132)	0 (0, 0.06)			0.088 (0.068, 0.108)	0.104 (0.07, 0.153)
	Hormone_therapies	count			3	3			3	3			3	3			3	3
		time			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)
		n			18 (13, 23)	5 (5, 8)			2 (0, 3)	2 (1, 3)			5 (4, 7)	5 (1, 5)			2 (0, 4)	0 (0, 0)
		post_p			0.88 (0.81, 0.9)	0.72 (0.61, 0.81)			0.61 (0.57, 0.65)	0.63 (0.63, 0.67)			0.75 (0.57, 0.81)	0.54 (0.54, 0.54)			0.62 (0.56, 0.67)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.056 (0.052, 0.078)	0.084 (0.064, 0.085)			0.067 (0.013, 0.121)	0 (0, 0.06)			0.1 (0.046, 0.139)	0.065 (0.013, 0.116)			0.027 (0.005, 0.049)	NA (NA, NA)
	Niraparib	count			4	4			4	4			4	4			4	4
		time			16 (10, 20)	16 (10, 20)			16 (10, 20)	16 (10, 20)			16 (10, 20)	16 (10, 20)			16 (10, 20)	16 (10, 20)
		n			16 (11, 22)	4 (1, 7)			3 (2, 5)	4 (1, 10)			2 (0, 3)	4 (2, 5)			3 (2, 4)	3 (1, 4)
		post_p			0.9 (0.8, 0.94)	0.72 (0.58, 0.77)			0.72 (0.55, 0.79)	0.75 (0.56, 0.92)			0.67 (0.64, 0.7)	0.75 (0.61, 0.79)			0.7 (0.59, 0.82)	0.7 (0.56, 0.86)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.053 (0.035, 0.067)	0.086 (0.063, 0.111)			0.107 (0.076, 0.135)	0.081 (0.018, 0.109)			0.046 (0.009, 0.082)	0.065 (0.014, 0.089)			0.092 (0.022, 0.113)	0.088 (0.018, 0.122)
	Taxel_therapies	count			9	9			9	9			9	9			9	9
		time			9 (7, 13)	9 (7, 13)			9 (7, 13)	9 (7, 13)			9 (7, 13)	9 (7, 13)			9 (7, 13)	9 (7, 13)
		n			9 (6, 13)	11 (7, 15)			0 (0, 2)	1 (0, 3)			3 (2, 5)	3 (2, 5)			1 (0, 3)	1 (0, 3)
		post_p			0.76 (0.69, 0.86)	0.81 (0.67, 0.88)			0.65 (0.56, 0.75)	0.57 (0.52, 0.63)			0.57 (0.53, 0.85)	0.55 (0.51, 0.7)			0.59 (0.51, 0.72)	0.62 (0.53, 0.63)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.078 (0.054, 0.116)	0.05 (0.03, 0.093)			0 (0, 0)	0 (0, 0.039)			0.081 (0, 0.142)	0.062 (0, 0.092)			0 (0, 0.078)	0 (0, 0.034)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Carboplatin	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)	10 (8, 12)
		n	6 (4, 8)	0 (0, 0)	6 (4, 8)	4 (3, 6)	5 (5, 5)	6 (5, 6)	1 (0, 2)	1 (0, 2)	2 (1, 3)	2 (1, 2)	2 (1, 3)	0 (0, 0)	2 (1, 2)	2 (0, 3)	2 (1, 4)	4 (1, 6)
		post_p	0.29 (0.2, 0.38)	NA (NA, NA)	0.34 (0.27, 0.41)	0.4 (0.37, 0.42)	0.22 (0.12, 0.33)	0.45 (0.41, 0.48)	0.46 (0.46, 0.46)	0.49 (0.49, 0.49)	0.45 (0.43, 0.48)	0.39 (0.31, 0.47)	0.35 (0.24, 0.46)	NA (NA, NA)	0.34 (0.31, 0.37)	0.12 (0.12, 0.12)	0.33 (0.27, 0.39)	0.46 (0.46, 0.46)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.161 (0.153, 0.169)	NA (NA, NA)	0.227 (0.154, 0.299)	0.203 (0.154, 0.253)	0.189 (0.09, 0.288)	0.112 (0.09, 0.135)	0.08 (0.08, 0.08)	0.095 (0.095, 0.095)	0.089 (0.018, 0.161)	0.171 (0.034, 0.307)	0.25 (0.218, 0.282)	NA (NA, NA)	0.209 (0.206, 0.212)	0.551 (0.551, 0.551)	0.245 (0.131, 0.359)	0.041 (0.041, 0.041)
	Hormone_therapies	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)	3 (3, 3)
		n	13 (13, 13)	2 (2, 2)	6 (6, 6)	3 (3, 3)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	1 (1, 1)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.2 (0.2, 0.2)	0.34 (0.34, 0.34)	0.36 (0.36, 0.36)	0.24 (0.24, 0.24)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.102 (0.102, 0.102)	0.292 (0.292, 0.292)	0.078 (0.078, 0.078)	0.206 (0.206, 0.206)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
	Niraparib	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)	28 (23, 28)
		n	22 (13, 70)	5 (2, 15)	10 (8, 33)	4 (2, 17)	10 (4, 18)	2 (1, 8)	3 (3, 7)	1 (1, 2)	2 (1, 4)	4 (1, 6)	3 (2, 7)	4 (2, 5)	2 (2, 4)	3 (3, 5)	2 (2, 4)	2 (2, 6)
		post_p	0.06 (0.05, 0.37)	0.39 (0.38, 0.39)	0.14 (0.11, 0.43)	0.44 (0.21, 0.47)	0.33 (0.17, 0.4)	0.32 (0.32, 0.34)	0.24 (0.19, 0.34)	0.37 (0.32, 0.38)	0.41 (0.28, 0.42)	0.36 (0.35, 0.37)	0.3 (0.27, 0.45)	0.35 (0.27, 0.46)	0.19 (0.18, 0.2)	0.28 (0.24, 0.3)	0.18 (0.14, 0.43)	0.34 (0.24, 0.42)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.106 (0.103, 0.185)	0.153 (0.113, 2.178)	0.23 (0.138, 0.234)	0.122 (0.106, 1.745)	0.142 (0.105, 0.184)	0.2 (0.111, 4.306)	0.296 (0.172, 0.441)	0.326 (0.234, 0.335)	0.287 (0.183, 0.304)	0.144 (0.14, 0.148)	0.148 (0.122, 0.389)	0.178 (0.155, 0.39)	0.418 (0.226, 0.877)	0.197 (0.121, 0.394)	0.218 (0.139, 0.299)	0.267 (0.181, 0.485)
	Taxel_therapies	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)
		n	6 (5, 8)	3 (3, 4)	3 (2, 10)	6 (5, 8)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 1)	3 (3, 4)	1 (0, 1)	1 (0, 4)	4 (1, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.44 (0.28, 0.46)	0.45 (0.45, 0.49)	0.48 (0.16, 0.48)	0.37 (0.33, 0.47)	0.24 (0.24, 0.24)	NA (NA, NA)	NA (NA, NA)	0.48 (0.48, 0.48)	0.46 (0.46, 0.48)	0.39 (0.31, 0.47)	0.43 (0.43, 0.43)	0.35 (0.28, 0.41)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.114 (0.083, 0.306)	0.185 (0.037, 0.192)	0.141 (0.028, 0.234)	0.128 (0.127, 0.131)	1.07 (1.07, 1.07)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0.124 (0.025, 0.211)	0.143 (0.029, 0.258)	0.712 (0.187, 1.236)	0.251 (0.216, 0.285)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
DRD+	Carboplatin	count					41	41	41	41					41	41	41	41
		time					24 (16, 34)	24 (16, 34)	24 (16, 34)	24 (16, 34)					24 (16, 34)	24 (16, 34)	24 (16, 34)	24 (16, 34)
		n					7 (2, 14)	7 (3, 14)	3 (2, 7)	3 (1, 6)					4 (1, 8)	3 (1, 8)	5 (2, 8)	4 (1, 7)
		post_p					0.38 (0.14, 0.46)	0.3 (0.12, 0.43)	0.33 (0.18, 0.46)	0.37 (0.22, 0.45)					0.35 (0.23, 0.47)	0.38 (0.19, 0.47)	0.38 (0.13, 0.48)	0.36 (0.15, 0.46)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.129 (0.087, 0.328)	0.13 (0.089, 0.243)	0.2 (0.104, 1.192)	0.203 (0.104, 0.4)					0.161 (0.107, 0.608)	0.149 (0.102, 0.597)	0.154 (0.101, 0.278)	0.195 (0.091, 0.593)
	Hormone_therapies	count					2	2	2	2					2	2	2	2
		time					26 (24, 27)	26 (24, 27)	26 (24, 27)	26 (24, 27)					26 (24, 27)	26 (24, 27)	26 (24, 27)	26 (24, 27)
		n					0 (0, 1)	2 (2, 2)	4 (3, 4)	7 (6, 8)					3 (2, 4)	1 (1, 1)	2 (1, 4)	6 (5, 8)
		post_p					0.42 (0.42, 0.42)	0.43 (0.41, 0.44)	0.24 (0.2, 0.28)	0.28 (0.22, 0.35)					0.27 (0.27, 0.28)	0.43 (0.38, 0.48)	0.27 (0.22, 0.32)	0.42 (0.35, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.123 (0.123, 0.123)	0.11 (0.108, 0.112)	0.241 (0.21, 0.272)	0.116 (0.105, 0.128)					0.362 (0.305, 0.419)	0.423 (0.246, 0.6)	5.716 (1.253, 10.18)	0.124 (0.079, 0.17)
	Niraparib	count					42	42	42	42					42	42	42	42
		time					26 (14, 34)	26 (14, 34)	26 (14, 34)	26 (14, 34)					26 (14, 34)	26 (14, 34)	26 (14, 34)	26 (14, 34)
		n					5 (2, 14)	6 (3, 18)	4 (1, 9)	3 (1, 7)					4 (1, 6)	4 (1, 8)	4 (2, 6)	4 (2, 8)
		post_p					0.29 (0.13, 0.42)	0.29 (0.13, 0.47)	0.38 (0.19, 0.46)	0.32 (0.18, 0.48)					0.33 (0.21, 0.44)	0.34 (0.2, 0.46)	0.36 (0.18, 0.48)	0.38 (0.2, 0.48)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.128 (0.088, 0.491)	0.134 (0.088, 0.374)	0.2 (0.117, 0.683)	0.247 (0.108, 1.097)					0.174 (0.115, 0.344)	0.187 (0.102, 0.662)	0.183 (0.091, 0.489)	0.161 (0.107, 0.372)
	Taxel_therapies	count					40	40	40	40					40	40	40	40
		time					26 (20, 34)	26 (20, 34)	26 (20, 34)	26 (20, 34)					26 (20, 34)	26 (20, 34)	26 (20, 34)	26 (20, 34)
		n					6 (2, 17)	5 (2, 10)	2 (1, 5)	2 (0, 5)					4 (1, 8)	3 (1, 6)	2 (1, 8)	2 (1, 5)
		post_p					0.32 (0.19, 0.45)	0.31 (0.17, 0.45)	0.35 (0.18, 0.46)	0.34 (0.21, 0.48)					0.36 (0.19, 0.47)	0.38 (0.28, 0.48)	0.36 (0.25, 0.48)	0.38 (0.26, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.124 (0.088, 0.226)	0.129 (0.087, 0.253)	0.204 (0.108, 0.612)	0.243 (0.125, 1.44)					0.187 (0.133, 0.446)	0.164 (0.106, 0.534)	0.168 (0.109, 0.709)	0.217 (0.117, 0.516)
TEfus+	Carboplatin	count		42		42		42		42		42		42		42		42
		time		20 (15, 35)		20 (15, 35)		20 (15, 35)		20 (15, 35)		20 (15, 35)		20 (15, 35)		20 (15, 35)		20 (15, 35)
		n		4 (1, 9)		6 (4, 16)		6 (2, 11)		4 (1, 6)		3 (1, 7)		3 (1, 8)		3 (1, 7)		3 (1, 7)
		post_p		0.3 (0.18, 0.45)		0.34 (0.16, 0.47)		0.35 (0.14, 0.47)		0.35 (0.19, 0.47)		0.37 (0.24, 0.46)		0.35 (0.2, 0.45)		0.36 (0.23, 0.48)		0.37 (0.17, 0.46)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.151 (0.076, 0.416)		0.157 (0.107, 0.311)		0.126 (0.086, 0.255)		0.155 (0.115, 0.539)		0.168 (0.096, 0.699)		0.185 (0.119, 0.786)		0.181 (0.108, 0.615)		0.173 (0.105, 0.318)
	Hormone_therapies	count		3		3		3		3		3		3		3		3
		time		26 (19, 28)		26 (19, 28)		26 (19, 28)		26 (19, 28)		26 (19, 28)		26 (19, 28)		26 (19, 28)		26 (19, 28)
		n		4 (2, 4)		9 (5, 18)		1 (0, 2)		2 (1, 2)		4 (3, 8)		3 (2, 5)		4 (3, 4)		2 (1, 4)
		post_p		0.36 (0.35, 0.4)		0.22 (0.18, 0.39)		0.44 (0.39, 0.49)		0.34 (0.25, 0.42)		0.38 (0.18, 0.46)		0.46 (0.25, 0.47)		0.42 (0.28, 0.43)		0.36 (0.31, 0.44)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.124 (0.091, 0.141)		0.153 (0.107, 0.333)		0.12 (0.103, 0.137)		0.827 (0.387, 0.924)		0.169 (0.143, 0.272)		0.211 (0.156, 0.542)		0.151 (0.11, 0.227)		0.166 (0.11, 3.035)
	Niraparib	count		30		30		30		30		30		30		30		30
		time		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)		22 (16, 34)
		n		4 (1, 14)		8 (4, 22)		5 (3, 10)		3 (1, 7)		3 (1, 6)		4 (2, 8)		4 (1, 8)		4 (1, 8)
		post_p		0.37 (0.13, 0.45)		0.38 (0.15, 0.48)		0.25 (0.13, 0.46)		0.38 (0.18, 0.48)		0.37 (0.22, 0.47)		0.4 (0.19, 0.49)		0.33 (0.16, 0.49)		0.34 (0.22, 0.49)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.146 (0.085, 0.747)		0.14 (0.102, 0.285)		0.155 (0.095, 0.413)		0.176 (0.11, 0.449)		0.206 (0.118, 0.654)		0.171 (0.095, 0.338)		0.136 (0.091, 1.132)		0.164 (0.096, 0.579)
	Taxel_therapies	count		48		48		48		48		48		48		48		48
		time		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)
		n		4 (2, 12)		10 (5, 21)		4 (1, 9)		2 (0, 5)		5 (3, 10)		5 (2, 10)		2 (0, 7)		2 (0, 4)
		post_p		0.31 (0.13, 0.45)		0.32 (0.1, 0.47)		0.33 (0.12, 0.45)		0.35 (0.25, 0.48)		0.39 (0.23, 0.48)		0.34 (0.16, 0.47)		0.35 (0.24, 0.47)		0.35 (0.2, 0.47)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.161 (0.077, 0.337)		0.146 (0.111, 0.238)		0.164 (0.106, 0.568)		0.188 (0.111, 1.131)		0.137 (0.104, 0.346)		0.15 (0.101, 0.458)		0.19 (0.105, 0.643)		0.195 (0.079, 0.768)
TP53- & AR-	Carboplatin	count	391	391			391	391
		time	20 (13, 31)	20 (13, 31)			20 (13, 31)	20 (13, 31)
		n	18 (8, 56)	5 (1, 14)			7 (3, 15)	7 (3, 15)
		post_p	0.18 (0.03, 0.45)	0.34 (0.16, 0.48)			0.33 (0.13, 0.47)	0.35 (0.13, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.115 (0.084, 0.182)	0.132 (0.081, 0.383)			0.126 (0.083, 0.309)	0.126 (0.081, 0.274)
	Hormone_therapies	count	2	2			2	2
		time	6 (6, 7)	6 (6, 7)			6 (6, 7)	6 (6, 7)
		n	24 (22, 25)	2 (2, 3)			0 (0, 1)	1 (0, 2)
		post_p	0.4 (0.36, 0.45)	0.12 (0.05, 0.19)			0.49 (0.49, 0.49)	0.19 (0.19, 0.19)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.071 (0.056, 0.085)	0.766 (0.7, 0.832)			0 (0, 0)	0.177 (0.177, 0.177)
	Niraparib	count	382	382			382	382
		time	21 (13, 32)	21 (13, 32)			21 (13, 32)	21 (13, 32)
		n	18 (8, 59)	5 (2, 15)			7 (2, 15)	7 (3, 16)
		post_p	0.18 (0.03, 0.45)	0.33 (0.13, 0.47)			0.33 (0.1, 0.48)	0.33 (0.13, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.115 (0.083, 0.19)	0.138 (0.082, 0.428)			0.132 (0.088, 0.34)	0.129 (0.081, 0.34)
	Taxel_therapies	count	396	396			396	396
		time	21 (13, 33)	21 (13, 33)			21 (13, 33)	21 (13, 33)
		n	19 (8, 59)	6 (3, 16)			6 (2, 15)	5 (2, 14)
		post_p	0.16 (0.02, 0.41)	0.28 (0.1, 0.46)			0.35 (0.15, 0.48)	0.35 (0.17, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.117 (0.086, 0.197)	0.137 (0.086, 0.317)			0.132 (0.079, 0.428)	0.127 (0.08, 0.39)
TP53+	Carboplatin	count			35	35			35	35			35	35			35	35
		time			20 (13, 35)	20 (13, 35)			20 (13, 35)	20 (13, 35)			20 (13, 35)	20 (13, 35)			20 (13, 35)	20 (13, 35)
		n			11 (6, 20)	6 (2, 13)			3 (1, 7)	4 (2, 8)			3 (2, 11)	3 (1, 8)			2 (1, 8)	3 (1, 6)
		post_p			0.28 (0.09, 0.47)	0.33 (0.16, 0.47)			0.34 (0.19, 0.48)	0.41 (0.26, 0.49)			0.35 (0.19, 0.49)	0.35 (0.13, 0.47)			0.38 (0.19, 0.49)	0.34 (0.14, 0.46)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.146 (0.11, 0.227)	0.143 (0.104, 0.516)			0.207 (0.122, 1.072)	0.155 (0.097, 0.268)			0.151 (0.095, 0.33)	0.198 (0.1, 0.814)			0.168 (0.094, 1.099)	0.247 (0.095, 0.766)
	Hormone_therapies	count			29	29			29	29			29	29			29	29
		time			20 (11, 29)	20 (11, 29)			20 (11, 29)	20 (11, 29)			20 (11, 29)	20 (11, 29)			20 (11, 29)	20 (11, 29)
		n			14 (6, 29)	8 (3, 15)			2 (0, 3)	2 (1, 5)			3 (1, 7)	3 (1, 7)			2 (0, 4)	2 (1, 4)
		post_p			0.28 (0.09, 0.42)	0.36 (0.12, 0.48)			0.33 (0.18, 0.49)	0.42 (0.28, 0.47)			0.31 (0.22, 0.44)	0.32 (0.18, 0.49)			0.35 (0.15, 0.47)	0.34 (0.21, 0.47)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.146 (0.112, 0.236)	0.157 (0.091, 0.344)			0.239 (0.117, 0.493)	0.17 (0.044, 1.247)			0.227 (0.142, 1.247)	0.196 (0.104, 0.456)			0.416 (0.075, 0.955)	0.228 (0.094, 1.164)
	Niraparib	count			30	30			30	30			30	30			30	30
		time			19 (12, 33)	19 (12, 33)			19 (12, 33)	19 (12, 33)			19 (12, 33)	19 (12, 33)			19 (12, 33)	19 (12, 33)
		n			10 (5, 40)	6 (4, 19)			3 (1, 8)	2 (1, 9)			3 (0, 7)	3 (1, 5)			3 (2, 6)	3 (1, 7)
		post_p			0.24 (0.12, 0.49)	0.38 (0.16, 0.46)			0.35 (0.18, 0.47)	0.33 (0.22, 0.48)			0.35 (0.23, 0.46)	0.38 (0.24, 0.48)			0.4 (0.22, 0.49)	0.35 (0.15, 0.48)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.159 (0.114, 0.416)	0.131 (0.1, 0.333)			0.166 (0.108, 1.105)	0.234 (0.116, 0.635)			0.168 (0.13, 0.55)	0.184 (0.12, 0.664)			0.181 (0.109, 0.324)	0.165 (0.093, 0.544)
	Taxel_therapies	count			29	29			29	29			29	29			29	29
		time			22 (9, 33)	22 (9, 33)			22 (9, 33)	22 (9, 33)			22 (9, 33)	22 (9, 33)			22 (9, 33)	22 (9, 33)
		n			11 (5, 27)	10 (5, 16)			2 (0, 5)	2 (0, 4)			4 (1, 11)	4 (2, 8)			2 (0, 5)	2 (1, 5)
		post_p			0.34 (0.17, 0.46)	0.25 (0.13, 0.43)			0.31 (0.19, 0.43)	0.4 (0.28, 0.49)			0.38 (0.19, 0.46)	0.35 (0.14, 0.48)			0.33 (0.21, 0.45)	0.36 (0.22, 0.49)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.143 (0.103, 0.246)	0.15 (0.108, 0.197)			0.292 (0.148, 0.545)	0.18 (0.108, 0.793)			0.174 (0.124, 0.523)	0.137 (0.07, 0.462)			0.205 (0.02, 0.733)	0.196 (0.107, 0.78)